I am always worrying about getting early-onset Alzheimers, thinking about how these genes may interact to cause beta-amyloid to accumulate much earlier. BIN1 has been shown to affect BACE1 trafficking and beta-amyloid production. Perhaps it is ridiculous to worry about BIN1 given its low odds ratio...

My mom developed severe dementia in December 2019 and started the Bredesen protocol in February of 2020. I found Dr. Gundry and Bredesen on youtube in December 2019. I bought Dr. Gundry's Longevity Paradox book and changed my diet right away. I am a 41-year-old male and getting myself checked out w...

Why not do a clinical trial for people with 1 or 2 APOE4 variants who are younger and asymptomatic (e.g. 20-50) and follow them and a group who did not receive gene therapy to see if replacing the variant(s) with APOE2 decreases the likelihood of developing Alzheimer's? The trial could answer the f...

thank you so much for this information. I am a 33 y.o female who has suffered on and off from insomnia. Knowing that i am 3/4 I have done everything possible to rectify this. Sometimes it works and I have good weeks , sometimes it doesnt. I had a really bad period where I had to be on trazadone for...

Thank you so much for responding! We do sound a lot alike. For me, I also make sure that I'm monitoring my vitamin levels (particularly B vitamins) and am taking methylated forms of the B vitamins in addition to monitoring my homocysteine levels. I also pay out of pocket for blood testing every yea...

1. Am I overreacting? Should I be worried and immediately contact my Dr. based on this info or am I doing the right things currently and just need to relax? 2. How do you most effectively broach the subject with your Dr? (My health provider is notoriously stingy with testing). What tests should I a...

I don't see much discussion on this fairly readily available bile salt. Supposedly it inhibits apoptosis. from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030606/ "TUDCA improves apolipoprotein E4 (APOE4) macrophage survival and function. APOE4 and APOE3 have important functions in binding t...

I was using Prostophane supplements, available via chilled transport in the EU. As far as I know, it's the only stabilised sulforaphane available world wide according to Dr Jed Fahey. Perhaps an email to Dr Rhonda Patrick or Dr Fahey would be helpful, if you were intent on taking this product. Here...

Hi all, Our doctor has prescribed Glutathione for my mom but there's so much out there I don't know what to get. I know we want liposomal, and reduced, but other than that I don't know what's best. I've subscribed to Consumerlabs.com but they don't seem to have anything on this particular type of s...

I am new to this site. I have a sister-in-law with the beginning symptoms of alzheimers, and since my husband and I are in our 70's, we naturally want to prevent any future occurrences, if possible. Question: This relative married a man who had Huntington's (a degenerative brain disorder), and unfo...