Search found 119 matches

by Quantifier
Sun Sep 10, 2023 6:32 pm
Forum: Science and Research
Topic: Longitudinal study: Vitamin D supplementation associated with 40% lower dementia incidence
Replies: 7
Views: 354

Re: Longitudinal study: Vitamin D supplementation associated with 40% lower dementia incidence

Do be careful with higher than recommended vitamin D serum levels. At some point (which may vary individually) they may cause heart palpitations (this happened to a friend of mine).
by Quantifier
Sat Aug 19, 2023 11:37 pm
Forum: Science and Research
Topic: Thomas Dayspring talk: ApoE in the Periphery and in the Brain
Replies: 10
Views: 819

Re: Thomas Dayspring talk: ApoE in the Periphery and in the Brain

Tincup wrote: Tue Aug 08, 2023 7:11 pm
From my limited understanding, HDL quantity seems to have a "J" shaped benefit distribution.
I found a short video by Gil Carvalho about J shaped curves.
by Quantifier
Wed Aug 09, 2023 8:27 am
Forum: Science and Research
Topic: Thomas Dayspring talk: ApoE in the Periphery and in the Brain
Replies: 10
Views: 819

Re: Thomas Dayspring talk: ApoE in the Periphery and in the Brain

From my limited understanding, HDL quantity seems to have a "J" shaped benefit distribution. Beware of the J shape. Often J-shaped curves for health outcomes are seen when measurements are taken at one point in time, and the apparent 'optimal' level turns out to be very different from the...
by Quantifier
Tue Aug 01, 2023 5:44 pm
Forum: Prevention and Treatment
Topic: Chronically low HRV
Replies: 4
Views: 240

Re: Chronically low HRV

I have been able to raise my HRV by doing breathing exercises at bedtime. 10 rounds of inhaling for a count of 4, holding my breath for a count of 7, exhaling for a count of 8. But it only works for nights when I get to spend at least 5-6 hours in bed. I don't think these exercises can overcome the ...
by Quantifier
Sat Jul 29, 2023 4:00 am
Forum: Science and Research
Topic: Thomas Dayspring talk: ApoE in the Periphery and in the Brain
Replies: 10
Views: 819

Re: Thomas Dayspring talk: ApoE in the Periphery and in the Brain

I haven't listened to this talk, but Dr Dayspring has linked several times to papers that say the brain cannot get cholesterol from serum lipoprotein particles, as they do not cross the blood-brain barrier, the brain needs to make its own cholesterol in oligodendrocytes. That the brain is a separate...
by Quantifier
Fri Jul 28, 2023 4:29 am
Forum: Science and Research
Topic: HSV-1 and E4
Replies: 4
Views: 340

Re: HSV-1 and E4

The newer paper (the one in my second link) calculates the difference in dementia rates between the vaccine-eligible population as a whole and the slightly older vaccine ineligible as a whole. So they are not comparing 'people likely to have better health habits and seek medical care' to those who a...
by Quantifier
Thu Jul 27, 2023 7:30 am
Forum: Science and Research
Topic: HSV-1 and E4
Replies: 4
Views: 340

Re: HSV-1 and E4

Oops, sorry, I linked to the wrong paper. This one has the more clear boundary by date of birth: Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases . Because they correlated dementia risk to age rather than to vaccination status they overcame the healthy subject b...
by Quantifier
Thu Jul 27, 2023 7:20 am
Forum: Science and Research
Topic: HSV-1 and E4
Replies: 4
Views: 340

Re: HSV-1 and E4

There was a recent publication looking at the effect of the Shingles vaccine on development of AD. Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020 . In this study the researchers took advantage of the fact that there was a sharp cut-off for eligibility for the vaccin...
by Quantifier
Wed Jul 19, 2023 11:31 am
Forum: Our Stories
Topic: has anyone experienced e4/e4 issues with life insurance or long term care insurance ?
Replies: 8
Views: 687

Re: has anyone experienced e4/e4 issues with life insurance or long term care insurance ?

finally, i'm wondering if life insurance companies will turn me down because of e4/e4. as of now, the only record of my status is with 23andme. i assume that information is inaccessible by an insurance company. but if i confide in my doctor, then this will potentially go into my record and presumab...
by Quantifier
Thu Jul 13, 2023 11:30 pm
Forum: Prevention and Treatment
Topic: Calcium
Replies: 7
Views: 230

Re: Calcium

I am having the hardest time of getting the standard 1200 mg of calcium recommended for those of us over 60 years old on 1300 calories (for weight loss) without supplements (cardiologist advises against supplements) and without dairy!!!! And I am in osteoporosis now, so I'm really in need of a solu...