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by ApropoE4
Tue Nov 23, 2021 8:09 am
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 29
Views: 11325

Re: Gene Therapy Trial for ApoE4 Homozygotes

Serious complications in phase 1 clinical trials that are not cancer related are about one in 300. We could speculate about this particular trial being possibly safer than average due to the nature of the vector, but since there are many unknowns it's best to just stick with that figure and assume t...
by ApropoE4
Mon Nov 01, 2021 1:23 pm
Forum: Prevention and Treatment
Topic: Dr that doesn't believe me
Replies: 12
Views: 497

Re: Dr that doesn't believe me

Statins are so widely (and successfully) prescribed that any large effect on AD (even if only in 4/4 or 3/4 carriers) would have manifested itself by now and therefore this should not be a consideration.
by ApropoE4
Sat Sep 11, 2021 12:29 pm
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 29
Views: 11325

Re: Gene Therapy Trial for ApoE4 Homozygotes

I think the study was / is for LX1001, but they just raised $100mm for further trials (I believe including LX1020 and 1021)

https://www.lexeotx.com/post/lexeo-ther ... -financing
by ApropoE4
Sun Aug 01, 2021 8:46 am
Forum: Science and Research
Topic: COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Replies: 111
Views: 9392

Re: COVID-19 RNA Based Vaccines and the Risk of Prion Disease

I'm happy you now agree there are no 45,000 bodies and their families hidden away at a government facility, and that the vaccines give you a 99.9% protection from covid related blood clots. Now let's talk about PCR tests - for many months we've seen positivity rates in nyc of around 1% or less. If P...
by ApropoE4
Sun Aug 01, 2021 7:50 am
Forum: Science and Research
Topic: COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Replies: 111
Views: 9392

Re: COVID-19 RNA Based Vaccines and the Risk of Prion Disease

It is increasingly difficult to ignore, however, that there are short-term problems for many people I think it's very useful to replace "many people" with actual figures when discussing safety. A quick google search says about 350 cases of vaccine related clotting have been reported. &quo...
by ApropoE4
Sat Jul 31, 2021 10:52 am
Forum: Science and Research
Topic: COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Replies: 111
Views: 9392

Re: COVID-19 RNA Based Vaccines and the Risk of Prion Disease

What are some of those early treatments that are not being given to patients despite being proven highly effective in preventing hospitalization?
by ApropoE4
Thu Jul 29, 2021 9:20 am
Forum: Science and Research
Topic: COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Replies: 111
Views: 9392

Re: COVID-19 RNA Based Vaccines and the Risk of Prion Disease

It is increasingly difficult to ignore, however, that there are short-term problems for many people I think it's very useful to replace "many people" with actual figures when discussing safety. A quick google search says about 350 cases of vaccine related clotting have been reported. Let'...

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