Hi - I'm curious if others take a daily choline supplement to reduce lipid accumulation in the brain caused by APOE4? If so, what type of choline do you take? There are several forms, including: phosphatidylcholine, CDP-choline, lecithin, and Alpha-GPC (L-alpha-glycerylphosphorylcholine). Also, any ...

Hi giftsplash - Polygenic scores are difficult to interpret for several reasons. First, for most complex diseases, only a fraction of the genetic heritability is known. For example, let's say for your disease your polygenic score is calculated from 10 variants (SNPs). Those 10 variants may only be a...

Last December Emmanuel Mignot's lab at Stanford University published a pre-print showing that a genetic variant common among people of European descent protects against Alzheimer's (link to pre-print: https://www.medrxiv.org/content/10.1101/2021.12.26.21268354v1). While several genetic variants that...

Very interesting theory regarding tubers :D unfortunately, my research is focused more on recent developments (last 10kya), so I cannot contribute much to your theory. Although it would be great if you could provide any sources for your theory :) Regarding the carb variant, AD is not (at least dire...

Thank you for your thoughts and ideas -- I really appreciate them and will follow up!

Hi, I recently sequenced my genome and discovered I'm homozygous for the ApoE4 polymorphism (E4/E4). I also have other mutations, besides ApoE4, that further increase my chances of developing Alzheimer's. I'm 44 yrs. old and a molecular biologist by training. I have a PhD and currently lead the rese...