Search found 239 matches

by aphorist
Mon Apr 22, 2024 3:12 am
Forum: Science and Research
Topic: ADMA as Early Warning Sign
Replies: 16
Views: 2232

Re: ADMA as Early Warning Sign

https://youtu.be/T5BEB0g6rBc?si=AiulTADwQR1PQJmY&t=309

Peter Attia comments on ADMA in the context of a larger discussion on blood pressure w/ Rhonda Patrick.
by aphorist
Sun Apr 21, 2024 12:54 pm
Forum: Science and Research
Topic: Hopeful Peter Attia Podcast with John Kastelein
Replies: 9
Views: 11802

Re: Hopeful Peter Attia Podcast with John Kastelein

OfficeSpace wrote: Sat Apr 20, 2024 6:35 am Thank you for the video link with timing cue and the attached notes (though the embedded hyperlinks do not work for me)!
See if this fixes it.
by aphorist
Mon Apr 15, 2024 3:52 am
Forum: Science and Research
Topic: While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
Replies: 0
Views: 173

While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain

https://www.alzforum.org/news/research-news/while-fly-sleeps-its-glia-burn-neuronal-lipids-refresh-brain This is a really great overview of a mechanistic paper showing how neurons generate oxidized lipids, the lipids are shuttled to astrocytes (glia cells) that take up, the glia form lipid droplets,...
by aphorist
Sun Apr 14, 2024 4:20 am
Forum: Science and Research
Topic: Hopeful Peter Attia Podcast with John Kastelein
Replies: 9
Views: 11802

Re: Hopeful Peter Attia Podcast with John Kastelein

Beginning at 1:41:30 https://youtu.be/Jduj5SL5FNs?si=mB5cTOUKGc9T-jk7&t=6090

John Kastelein, MD PhD

Worth listening to for anyone interested in the functionality (or lack thereof) of ApoE4. Notes attached.
by aphorist
Sun Apr 14, 2024 2:09 am
Forum: Prevention and Treatment
Topic: has anyone tried semax?
Replies: 4
Views: 35407

Re: has anyone tried semax?

I've used Semax. It was recommended to me by a doctor. But I also have a complicating factor like a head injury/TBI. It worked for me, but I'm wary of taking any hormones, pro-hormone (excluding vitamin d), or peptides for any lengthy period of time. And when I say it worked, I only mean it was bene...
by aphorist
Sun Apr 14, 2024 2:04 am
Forum: Science and Research
Topic: Why do different types of saturated fat affect the ApoE4 brain differently?
Replies: 4
Views: 17586

Re: Why do different types of saturated fat affect the ApoE4 brain differently?

Not all SFA are the same. Short chain fatty acids are typically beneficial/neutral. Long chain SFA like palmitic acid would be associated with inflammation.
by aphorist
Sat Mar 16, 2024 7:32 am
Forum: Science and Research
Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Replies: 24
Views: 31425

Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells

Thanks so much for these notes and papers, JNB. They are truly great thoughts and points.
by aphorist
Sun Mar 10, 2024 9:20 am
Forum: Science and Research
Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Replies: 24
Views: 31425

Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells

interesting paper and work. sort of creates more questions than answers, but every little step forward is useful.
by aphorist
Sun Mar 10, 2024 8:33 am
Forum: Science and Research
Topic: Homotaurine (tramiprosate) appears to be a structure corrector
Replies: 79
Views: 222989

Re: Homotaurine (tramiprosate) appears to be a structure corrector

Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper. I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine thro...
by aphorist
Sun Mar 10, 2024 8:27 am
Forum: Prevention and Treatment
Topic: Periodontitis / Gingivitis / Gum Disease in E4/E4
Replies: 40
Views: 95464

Re: Periodontitis / Gingivitis / Gum Disease in E4/E4

Does anyone know how to be tested for P. Gingivalis? Additionally, I found these interesting papers re: P Gingivalis Kobayashi, R., Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci Rep 7, 545 (2017). https:/...