Search found 233 matches

by aphorist
Sat Mar 16, 2024 7:32 am
Forum: Science and Research
Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Replies: 16
Views: 2350

Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells

Thanks so much for these notes and papers, JNB. They are truly great thoughts and points.
by aphorist
Sun Mar 10, 2024 9:20 am
Forum: Science and Research
Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Replies: 16
Views: 2350

Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells

interesting paper and work. sort of creates more questions than answers, but every little step forward is useful.
by aphorist
Sun Mar 10, 2024 8:33 am
Forum: Science and Research
Topic: Homotaurine (tramiprosate) appears to be a structure corrector
Replies: 77
Views: 131248

Re: Homotaurine (tramiprosate) appears to be a structure corrector

Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper. I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine thro...
by aphorist
Sun Mar 10, 2024 8:27 am
Forum: Prevention and Treatment
Topic: Periodontitis / Gingivitis / Gum Disease in E4/E4
Replies: 10
Views: 390

Re: Periodontitis / Gingivitis / Gum Disease in E4/E4

Does anyone know how to be tested for P. Gingivalis? Additionally, I found these interesting papers re: P Gingivalis Kobayashi, R., Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci Rep 7, 545 (2017). https:/...
by aphorist
Sat Feb 24, 2024 7:56 pm
Forum: Science and Research
Topic: Homotaurine (tramiprosate) appears to be a structure corrector
Replies: 77
Views: 131248

Re: Homotaurine (tramiprosate) appears to be a structure corrector

I'm just catching up on this thread and material. It reminds me somewhat of EPPS: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques https://www.nature.com/articles/ncomms9997 https://forums.apoe4.info/viewtopic.php?t=1957 I hav...
by aphorist
Sat Feb 24, 2024 4:56 pm
Forum: Prevention and Treatment
Topic: Modifiable risks and APOE 4/4
Replies: 7
Views: 670

Re: Modifiable risks and APOE 4/4

I'd be careful of Attia's general guidance for health and then applying it to a E4/4. He seems to advocate a higher protein intake, that could be problematic for some people without some kind of fasting regimen or intermittent restriction.
by aphorist
Sun Feb 18, 2024 9:01 am
Forum: Prevention and Treatment
Topic: Labcorp's p-tau 181 pricing
Replies: 14
Views: 1160

Re: Labcorp's p-tau 181 pricing

It seems like p-217 is available from Alzpath, although I can't seem to find where exactly -- as they apparently don't have a doctor/provider locator tool on their website for prospective test candidates. Does anyone know when/where pTau-217 might be available from larger providers like Labcorp or Q...
by aphorist
Mon Feb 12, 2024 7:13 am
Forum: Prevention and Treatment
Topic: Labcorp's p-tau 181 pricing
Replies: 14
Views: 1160

Re: Labcorp's p-tau 181 pricing

Is there a quick wiki or explanation somewhere that gives an overview of p-181 vs. 42/40 vs. p-217 ?

I think I know some of the answers, but I just wonder if there is a consolidated set of info somewhere.
by aphorist
Sun Feb 04, 2024 2:31 am
Forum: Prevention and Treatment
Topic: ApoB question for lipid nerds
Replies: 13
Views: 1154

Re: ApoB question for lipid nerds

My guess is that the lower LDL-P would be reflected as each low density lipoprotein has an ApoB attached that has nothing to do with it's cargo — LDL-C. Does that seem to be correct? The discordance and hypothesized benefit is that lower ApoB with the same LDL-C would require lower LDL-P. And conse...
by aphorist
Sun Feb 04, 2024 2:24 am
Forum: Science and Research
Topic: elevated LDL from fasting versus exogenous fat consumption
Replies: 10
Views: 1483

Re: elevated LDL from fasting versus exogenous fat consumption

One could probably self-test this over a period of time (say 60 days) by doing the two routines 1. Intermittent fasting (say one meal a day, 3-8% or less SFA intake) and 2. diet higher in SFA, regular eating. (three meals a day, 15%+ SFA). Then go get a NMR lipoprofile after each 60 day period and s...