What is her exercise routine? You can change her diet all you want. But if she is frail/small w/ low BMI, she must have metabolically active lean mass/tissue that can utilize the diet intake.

She needs to walk every day and lift weights 2-3x a week. Yoga, tai chi, etc.

Interesting paper on how the amyloid/tau cascade conspire to increase hif1a, which downregulates glycolysis, decreases lactate production in astrocytes and starves neurons. drug-based inhibition of IDO1 (class of cancer drugs) and inhibition of KYN restore lactate production. https://www.science.org...

Decent review of DHA in ApoE4 from Ebright, et al

I'm (after a career switch) in longevity-oriented research and biotech (in several capacities) and have decided to focus on APOE as a target, especially now that my parents have entered their late autumnal years. Makes sense. I had to add a second apoe4.info bookmark in my Chrome specifically for p...

Ezetimibe has a half-life of ~22 hours. It's pretty long. My 5 minutes of thought on this would be to take Omega-3 fatty acids in the morning with coffee (5-7 AM), take the Ezetimibe at 10 AM and have my first meal at 11 AM - 12 PM. It would be nice to get an an Omega blood test to look at it over t...

No idea. I wasn't aware they moved on and what I'm seeing in this presentation (https://www.prnewswire.com/news-releases/gabaeron-presents-promising-preclinical-data-on-stem-cellbased-therapy-for-alzheimers-disease-301409130.html) from GABAeron seems like a rather exotic change in direction. Do you ...

Never heard of this. Closest thing I'm aware of is Yadong Huang, MD, PhD at Gladstone working on ApoE4 structure correctors to make E4 work like E3.

Thx for posting this Brian.

I would think they should take interest in your sdLDL, HDL and the totality of an advanced lipid profile. Often hard to know exactly what's going on with a person just through a basic LDL figure in isolation.

Just FYI of a scientist's regimen. She is ApoE 3/4. Provided on her recent podcast. Omega-3 - Metagenics EPA DHA 2400 Vitamin D with K2 - Pure Encapsulations Multivitamin - Pure Encapsulations "One Multivitamin" Magnesium Glycinate - Pure Encapsulations Sulfurophane - Avmacol Alpha Lipoic ...

That’s very interesting! No way I could get my doc to prescribe me Efavirenz though. I’ve thought about doing very low dose crestor. Still debating. I do have high ldl and apob that I am trying to reduce with diet before my next physical. There are a few papers and RCTs with Efavirenz for Alzheimer...