Search found 3351 matches

by J11
Mon Feb 05, 2024 8:53 pm
Forum: Our Stories
Topic: New, almost 50, with 1 copy Apoe4 and a family history.
Replies: 8
Views: 536

Re: New, almost 50, with 1 copy Apoe4 and a family history.

technimom, I know how much dementia can freak people out, though I would suggest that you dial back this fear. Perhaps over the next few months to year we will see an inexpensive blood test that potentially could give you warning of approaching onset of AD dementia 15 years forward. That would be in...
by J11
Sat Feb 03, 2024 9:27 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Finally to get all caught up I will thank Theresa B once again for the comment. This comment started by quoting my celebratory mood. What was that celebration all about? That celebration was considering the announcement of an inexpensive ptau 217 blood test that could help people be made aware of AD...
by J11
Sat Feb 03, 2024 9:20 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Thank you again Theresa B, for your yet earlier post.

Previous comments about e44s are in the back stacks of the thread.

In fact, yes, epsilon 4 is a part of the genetic history of my family, though in the recent past this
genotype has not contributed to the dementia phenotype.
by J11
Sat Feb 03, 2024 9:18 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

NF52 thank you for your post. I appreciate that you were able to locate my previous posts that demonstrate that I do engage with topics related to epsilon 4 etc.. With mabs it has been somewhat less clear what the benefits for e44 might be and there is increased ARIA and other risks. This lack of cl...
by J11
Sat Feb 03, 2024 9:13 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Thank you Theresa B for your earlier post. I try to provide substantiation for all my comments. My current interest has been from the presentations at CTAD 2023. At this conference, a model was introduced that suggested 95% disease slowing in those who were 2 years before the average in a derived mo...
by J11
Sat Feb 03, 2024 9:08 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Thank you Julie G for your comment. My recent posts have been in reference to the reports from CTAD 2023 which has shifted my understanding of the benefits of mab treatment. The toplines that have been the focus of this thread did not identify the responder class of mabs. The update from CTAD is giv...
by J11
Sat Feb 03, 2024 8:57 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Fiver thank you for your comment. I realize that I am spending thread capital on the recent reports from CTAD; there would seem to be not that much in the way of payback for the posts. Yet, I want to be honest about what I am now seeing. These statements are falsifiable and so they will not be "...
by J11
Sat Feb 03, 2024 8:46 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Thank you for your comment Tincup. Perhaps you should type Celebration into a forum search and then include J11 as the contributor and then select topic titles. What is actually surprising is how many of these celebration threads actually were worth celebrating. I wanted to have these Celebration th...
by J11
Sat Feb 03, 2024 8:36 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

The inbox is jammed up! Time to do a fast run through. Thank you for your comment Theresa B. Yes, it is amazing how much progress there has been in AD science since the accelerated approval of Aducanumab. It would seem that the accelerated approval of Aducanumab also helped accelerate Alzheimer's cl...
by J11
Fri Feb 02, 2024 5:47 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 338959

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

J11 is profoundly grateful for the clinical development of Aducanumab. Centuries of my family, generation after generation after generation -- consecutively, have lived with progressive and severe Alzheimer's dementia. Until the development of Aducanumab, there had not been a disease modifying treat...