Search found 2494 matches

by J11
Wed Jun 29, 2022 12:06 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Lecanemab Primary Completion!
Replies: 1
Views: 72

Re: Celebration Thread: Lecanemab Primary Completion!

The Core completion date for the Lecanemab Clarity trial is now September 15th.
Party delayed by a week.


https://www.timeanddate.com/countdown/p ... nt=cursive
by J11
Tue Jun 28, 2022 6:15 pm
Forum: Prevention and Treatment
Topic: The End of Alzheimer's
Replies: 4
Views: 311

Re: The End of Alzheimer's

Flora, it's brilliant! The supercomputer can figure out everything for everyone! Why, it will be truly panglossian-- the best of all possible worlds! I suppose getting us out of dementia prison will allow us to make some improvements that the non-dementeds might never have thought of (or thought of ...
by J11
Sun Jun 26, 2022 6:36 pm
Forum: Prevention and Treatment
Topic: The End of Alzheimer's
Replies: 4
Views: 311

Re: The End of Alzheimer's

I have been reading up on autonomous vehicle navigation technology. Interestingly, it appears that perhaps over the medium term that motor vehicle mortality could be one of the few leading causes that might almost disappear. If we were to let a supercomputer drive our cars, then there would probably...
by J11
Thu Jun 23, 2022 4:28 pm
Forum: Prevention and Treatment
Topic: The End of Alzheimer's
Replies: 4
Views: 311

Re: The End of Alzheimer's

Just to be clear about what I suspect might happen with the AD rate over the next 10 years, we could see something similar to the figure below. It would not be overly surprising if it were even more rapid than a simple linear decline. It might not take a decade to reach super-low AD rates. Stopping ...
by J11
Thu Jun 23, 2022 3:54 pm
Forum: Prevention and Treatment
Topic: The End of Alzheimer's
Replies: 4
Views: 311

The End of Alzheimer's

With all of the emerging powerful AD treatment rapidly approaching it has me thinking about what happens after AD has been conquered. This motivated me to look at the long term figures for the leading causes of mortality. The three figures below capture most of the leading causes of mortality over t...
by J11
Wed Jun 22, 2022 8:19 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Lecanemab Primary Completion!
Replies: 1
Views: 72

Celebration Thread: Lecanemab Primary Completion!

It appears that I neglected to include a countdown for the Lecanemab Phase 3 Clarity Primary Completion date. From all that we know about Aducanumab and the dataset that has accumulated for the anti-amyloid mabs, it is not unrealistic to expect a celebration sometime after the primary completion whe...
by J11
Sun Jun 19, 2022 12:18 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Simufilam!
Replies: 3
Views: 111

Re: Celebration Thread: Simufilam!

The above figures provide some of the background. 3 points on ADAS-cog11 at 12 months is quite a bit. I like to see that the second phase 3 is going out to 76 weeks. With these new anti-ADs it seems wise to me to let the gains accumulate. Some of the earlier AD drugs were only tested out to ~24 week...
by J11
Sun Jun 19, 2022 12:12 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Simufilam!
Replies: 3
Views: 111

Re: Celebration Thread: Simufilam!

AD Clinical 4.PNG
AD Clinical 3.PNG
by J11
Sun Jun 19, 2022 12:11 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Simufilam!
Replies: 3
Views: 111

Re: Celebration Thread: Simufilam!

AD Clinical 2.PNG
AD Clinical.PNG
by J11
Sun Jun 19, 2022 12:11 pm
Forum: Prevention and Treatment
Topic: Celebration Thread: Simufilam!
Replies: 3
Views: 111

Celebration Thread: Simufilam!

Sorry everyone, I just want to catch up with all the drugs in the development that I have not focused on to date. If you want to find the good ones just search in the top right for "Celebration"; these are the good threads. I have 8 unique Celebration threads now; for some reason I decided...