Big news everyone! CTAD 2023 is all ready to go for late October. Last year was more late November, so I had thought that we might be 2 months away .. but no 1 month away! I suppose timing wise San Francisco is more late fall in early December, and Boston is more late fall in early November and more...

Sorry everyone I have a great post idea but I am too lazy to write it up fully now so I will just give a teaser and a reminder to myself so that I do not forget it.

Note to self: Infectious optimism vs. Infectious pessimism: the role in AD.

NF52, this is what I was thinking about. there is this memory impairment that starts at Braak stage II and then global cognition declines at stage III. In the other figure we see that memory declines 10 years before AD proper. I do not think that this aspect has been considered enough on thread. The...

That's the spirit Chicagogirl! Yes, all of us nitpickers are so often annoying. I have learned a certain appreciation of getting the topline reported in 24 point font and then everything else I am usually not that sure about. So yes the Georgia Dementia Net is something to celebrate. In the fine pri...

Yes, that is a great point about the need to reduce amyloid in the timeframe of the mab trial. I posted the figure from the Aducanumab trials many times on thread and it was quite startling. The patients who had not reached amyloid negativity after 18 months quite often progressed into rapid cogniti...

Yes, I was not all that impressed either with this newest article. I wasn't able to make it through the abstract without arguing about several of the summary points -- actually all of the non-literal statements made. Below is my color highlighting of the abstract. Anything in red are items that I fe...

I think,
"Progress - it happens one mistake at a time."

might need to be updated to:
"Progress -- it happens one celebration at a time." Yeah!

Chicagogirl, I am surprised that memory impairment was so emphasized in the flyer. Typically the memory impairment stage is years usually around 10-15 years before the onset of the dementia stage. That was how it was with us. We were coping with all sorts of memory issues and misplacing things for a...

NF52, this is very exciting! I have been worried lately that there did not seem to be that much activity on clinicaltrialsgov for Lecanemab. I wanted to see some more trials start up: it looks like there is now a big one with the Georgia Net. As I noted in my previous post, I think it is exciting th...