Search found 1543 matches

by NF52
Thu Aug 11, 2022 3:42 pm
Forum: Science and Research
Topic: APOLLOE4 Study: Are you or someone you know struggling with memory loss?
Replies: 9
Views: 2140

Re: APOLLOE4 Study: Are you or someone you know struggling with memory loss?

Ah, thank you for the update. I received this note yesterday from my contact at Sano Genetics: I hope you are well. I wanted to reach out today for two reasons. First, it looks like an individual from your community successfully pre-screened for the study last week. We are working on getting that i...
by NF52
Thu Aug 11, 2022 9:31 am
Forum: Prevention and Treatment
Topic: CTAD 2022 -- Endgame for AD
Replies: 7
Views: 259

Re: CTAD 2022 -- Endgame for AD

Alexia, thank you for posting to the thread and gaining a preview of the excitement available for interns on the APOE4 site. This is the most exciting moment in the century long history of AD clinical research. It does not get better than this!... I have already ordered my 2 cans of cashews and cho...
by NF52
Wed Aug 10, 2022 10:42 am
Forum: Science and Research
Topic: APOLLOE4 Study: Are you or someone you know struggling with memory loss?
Replies: 9
Views: 2140

Re: APOLLOE4 Study: Are you or someone you know struggling with memory loss?

Hi all. This phase of the APOLLOE4 study has concluded. The study organizers have asked me to let you know that this opportunity is no longer available. When/if they have further updates, we'll be happy to share them. Julie, I think the study that is no longer accepting participants is the the Gene...
by NF52
Tue Aug 09, 2022 8:56 am
Forum: Science and Research
Topic: alpha lipoic acid causes a homocystein rise
Replies: 5
Views: 380

Re: alpha lipoic acid causes a homocystein rise

...usually 2 g betain. 6 months ago I increased Bt to 7 g daily... 谢谢您的提醒。并且感谢您提供的降低同型半胱氨酸的配方,我想问下Bt是什么物质?我没查到。 The following is the English translation of the software, which may not be accurate. Please forgive me Thank you for your reminder. And thank you for the formula to reduce homocysteine,I ...
by NF52
Wed Aug 03, 2022 1:56 pm
Forum: Prevention and Treatment
Topic: Still trying to make sense if it is worth APOE4 to get a vaccine for Shingles and VZV?
Replies: 10
Views: 386

Re: Still trying to make sense if it is worth APOE4 to get a vaccine for Shingles and VZV?

Does anyone have any concerns that none of the Alzheimer/vaccine studies were done with Shingrix but with Zostavax which a different type of vaccine? "FDA licensed Shingrix (GSK), a recombinant shingles vaccine on October 20, 2017; therefore, most Shingrix-vaccinated subjects are not included ...
by NF52
Tue Aug 02, 2022 5:39 pm
Forum: Prevention and Treatment
Topic: Still trying to make sense if it is worth APOE4 to get a vaccine for Shingles and VZV?
Replies: 10
Views: 386

Re: Still trying to make sense if it is worth APOE4 to get a vaccine for Shingles and VZV?

Curious what everyone is thinking on this. Do you favor Shingrix or Zostavax or both? The CDC hasn't always been at the top of they game lately, but this resource on Shingrix lays out what seems to me to be a convincing case. . https://www.cdc.gov/vaccines/vpd/shingles/public/shingrix/index.html My...
by NF52
Mon Aug 01, 2022 9:37 am
Forum: Prevention and Treatment
Topic: Celebration Thread: Lecanemab Primary Completion!
Replies: 4
Views: 299

Re: Celebration Thread: Lecanemab Primary Completion!

Lecanemab given priority review with PDUFA of January 6, 2023. This is likely to be approval based on documented safety and efficacy of the outcome of reducing biomarkers of AD pathology: amyloid beta and tau There is also mention that full approval could be sought in March of 2023. I am not sure o...
by NF52
Mon Aug 01, 2022 7:45 am
Forum: Prevention and Treatment
Topic: AAIC 2022 has begun!!!
Replies: 3
Views: 337

Re: AAIC 2022 has begun!!!

I have the good fortune of being able to virtually attend this conference, so will post periodically what seem to be relevant results for ApoE4 carriers and those interested in current and upcoming clinical trials. Given the enormous scope of presentations and posters, no guarantees that I'll pick w...
by NF52
Fri Jul 29, 2022 8:01 am
Forum: Science and Research
Topic: Criminal investigation if biotech company manipulated research for Alzheimer's drug
Replies: 2
Views: 144

Re: Criminal investigation if biotech company manipulated research for Alzheimer's drug

From this short article reported by Reuters: Exclusive: Cassava Sciences faces U.S. criminal probe tied to Alzheimer's drug, sources say The U.S. Justice Department has opened a criminal investigation into Cassava Sciences Inc (SAVA.O) involving whether the biotech company manipulated research resu...
by NF52
Wed Jul 27, 2022 6:02 pm
Forum: Science and Research
Topic: CETP and APOE4
Replies: 2
Views: 185

Re: CETP and APOE4

Hello! This article ( CETP Genotype Modifies the Effect of Apolipoprotein ε4 on Memory Decline in Older Adults ) shows that APOE4 carriers with CETPV405V experiences a lower cognitive decline rate. So for these of your with rs5882 mutated from A to G, you will probably have slower decline. Good new...