I am an E3/E4 carrier in my 60s on HRT since start of menopause in my mid-50s. I have recently switched from continuous to cyclic (14 days/month) micronized progesterone (oral) with daily transdermal E2 gel. While the studies listed below are mouse models, the idea of cyclic progesterone makes sens...

This just came out April 9 as an Abstract only on April 9 in Neurology , (which has the catchphrase: "The most widely read and highly cited peer-reviewed neurology journal"). In a study of 194 people, median age 66, with a standard deviation of 10.7 years (so ages 55-77) with normal cognit...

NF52, Is this 2010 Finnish study trying to say their high ALZ rates are a function of (increased/improved) diagnostic reporting? I think it is saying two factors are affecting the prevalence rate: An increasing number of 90+ year olds, which they predicted in 2010 would increase the prevalence (ove...

... (see Finland's own reporting showing exploding ALZ rates over the last 40 years. Where is the critical thinking applied here to explain this disaster? The answer cannot simply be that Finnish people are living significantly longer than they were just 40 years ago or that molds are unique to Fin...

Just a quick question. If I have 2 APOE4 genes, but my brother doesn’t even have one, does this mean my parents only have one copy of the gene? I’m scared, but remain hopeful. Thank you! Hi Mich09! Genetics are confusing! We each have two copies of the ApoE gene (sometimes called an allele, or a va...

I should also note that I am apoe3/4... my mother's family all have high cholesterol, several of her relatives are on statins. My mother refused statins and is the one who got alzheimers. Yet she's also the one who got lupus, and I tend to think there may be some association with that. As for me, m...

This may be a stupid question but why would I want to have this test. I’m a 4/4 so I would think most likely not have good results. When I found out I was a 4/4 I was very stressed for a while but then came to terms with it and realized it was good to know so I could do the right things using a lot...

Hi, I am an E4 who is looking for a set of doctors that understand the special needs of E4/E4 carriers. I have tried looking for them in Sutter Health system but they seem to be few and far between. Any at Stanford, UCSF etc? Looking for a GP, Cardiologist, or nutritionist. Thank you!!! We have mem...

Thank you for the information but these post are a bit overwhelming and confusing. Could you please share the brand of omega three recommended and the amount I should be taking and phospholipid DHA w Tryglycerides. There are so many supplements that are not very good and honestly with 4 kids workin...

Hello, I know this is a rapa discussion but noticed you said you took simvastatin. I am curious about statins because it seems that most "experts" I've listened to say that APOE4's are different from others and should stay away from statins because we already are at risk of brain shrinkag...