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by NF52
Sat Oct 23, 2021 1:07 pm
Forum: Science and Research
Topic: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?
Replies: 4
Views: 448

Re: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?

Thanks so much BrianR! I love your optimism and want to get to that point myself. I will definitely check out that study. I really appreciate your feedback and personal story :) Hi Amy, Thanks for your kind words! Brian is a great, smart guy--but I think he's a good bit younger than this grandmothe...
by NF52
Sat Oct 23, 2021 12:45 pm
Forum: Science and Research
Topic: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?
Replies: 4
Views: 448

Re: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?

Is this something that can be used or is it only experimental? Looks promising Hi "Amy"! Good question! Right now this is in the very early stages of research. The "RCT" BrianR refers to, stands for "randomized controlled trial", which is required before a drug can be ...
by NF52
Tue Oct 19, 2021 1:24 pm
Forum: Prevention and Treatment
Topic: DTC testing with Quest Diagnostics
Replies: 5
Views: 454

Re: DTC testing with Quest Diagnostics

I would like to do some testing beyond what my doctor would be willing to prescribe. (For instance, my doctor thinks that as a healthy person there is no need to test lipids more than once in 5 years - or at least, that's what insurance would cover, apparently, while I want to see how my levels res...
by NF52
Sat Oct 16, 2021 4:35 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 768
Views: 81498

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Hope this helps, J11: I have looked on alzforum for the lecanemab article on September 10, though I was unable to find it. Might you supply a url? https://www.alzforum.org/therapeutics/lecanemab ... From what I remember there seemed to be some confusion about the enrollment from China into Clarity. ...
by NF52
Sat Oct 16, 2021 2:47 pm
Forum: Science and Research
Topic: "Not all Bad? APOE4 Sharpens Memory in Older People"
Replies: 1
Views: 796

Re: "Not all Bad? APOE4 Sharpens Memory in Older People"

Here's the article in Alzforum. This sure seems counter intuitive. Maybe not? Fc https://www.alzforum.org/news/research-news/not-all-bad-apoe4-sharpens-memory-older-people I think it falls under the banner of "Don't count us out yet!" Kirsty Lu and colleagues correlated APOE genotype, amy...
by NF52
Sat Oct 16, 2021 10:14 am
Forum: Our Stories
Topic: Introduction, that is all.
Replies: 1
Views: 713

Re: Introduction, that is all.

Hi. I'm Dee. I'm not use to using forums like this, so I hope you will all bear with me while I learn how to use it. I have not yet been tested for the APOE-4 gene, but seeing that there is a link between it and severe Covid has convinced me I should. Alzheimer's runs in my family. It would actuall...
by NF52
Thu Oct 14, 2021 4:57 pm
Forum: Practitioner Reviews
Topic: Karn Gupta, MD/ dr-gupta.com
Replies: 15
Views: 10403

Re: Dr Karn Gupta, MPH

Hola andresalva, cómo le fue a tu tía con el tratamiento? Nos podrías contar? Muchas gracias! Hola Assintperu. Muchas gracias por compartir tu experiencia. Realmente tenemos mucha esperanza y expectativas de que veamos mejoras con la enfermedad de mi tía. Ya tenemos los exámenes listos y segurament...
by NF52
Thu Oct 14, 2021 10:05 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 768
Views: 81498

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

...The phase 2 from leca has been out there for months now and it is only now that it has hit me: the APOE epsilon 4s had a large response to leca on the highest dose. On the 10 mg/kg biweekly dose the epsilon 4s (n=45) had a change from baseline of 0.096 points on ADCOMS versus a 0.180 change for ...
by NF52
Wed Oct 13, 2021 10:09 am
Forum: Science and Research
Topic: APOLLOE4 Study: Are you or someone you know struggling with memory loss?
Replies: 2
Views: 836

Re: APOLLOE4 Study: Are you or someone you know struggling with memory loss?

To provide our members with additional information that may be useful, here are some links about Alz-801, the study drug, which is a "prodrug" of tramiprosate. a subject of interest to many on the forum in the past. [And if anyone is interested in detailed info about any other current or u...
by NF52
Tue Oct 12, 2021 12:54 pm
Forum: Science and Research
Topic: Bumetanide for APOE4 Carriers
Replies: 1
Views: 736

Re: Bumetanide for APOE4 Carriers

Interesting article in "Nature Aging". In this research done by the Gladstone Institute, bumetanide, a common diuretic was found to reduce the instance of AD in APOE4 carriers.... The above is from a review on NIH.Gov: https://www.nih.gov/news-events/news-releases/precision-medicine-data-...

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