Search found 1570 matches

by NF52
Tue Sep 27, 2022 11:49 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1126
Views: 113302

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

... Lecanemab from what I currently understand is a very solid product: I am not even sure whether there will be enough time to have the Clarity results published before the FDA decides. I have been considering lately how a Lecanemab approval might filter through into the broader social landscape. ...
by NF52
Mon Sep 26, 2022 5:09 pm
Forum: Our Stories
Topic: What is the best Brain Scan for early signs of dementia
Replies: 4
Views: 68

Re: What is the best Brain Scan for early signs of dementia

Because I'm 48 (APOE 4/4) and not showing symptoms of dementia I have had a hard time finding a neurologist to help me determine which scan to get for a baseline of my brain. I'm attempting to schedule a scan on my own without a doctor's order, paid out of pocket.... Welcome 5Brains, I'm a 70 year ...
by NF52
Thu Sep 22, 2022 10:04 am
Forum: Science and Research
Topic: The association of APOE genotype with COVID-19 disease severity
Replies: 1
Views: 127

Re: The association of APOE genotype with COVID-19 disease severity

Near the beginning of the COVID pandemic, I found scientific journal papers claiming 3x to 4x mortality for APOE4/4 compared to 3/3.... Recent papers are more scary. From www.nature.com/scientificreports, published 05 August 2022: https://www.nature.com/articles/s41598-022-17262-4.pdf The associati...
by NF52
Thu Sep 22, 2022 8:48 am
Forum: Prevention and Treatment
Topic: Dr. Richard Isaacson - FAU Center for Brain Health
Replies: 2
Views: 98

Re: Dr. Richard Isaacson - FAU Center for Brain Health

Hi all, does anyone know the status of Florida Atlantic University's new Center for Brain Health at the Schmidt College of Medicine in Boca Raton? I believe it was due to open this year but I can't seem to get much information other than that. It's my understanding that Dr. Isaacson left Weill Corn...
by NF52
Wed Sep 21, 2022 3:23 pm
Forum: Prevention and Treatment
Topic: Exercise EVEN BETTER for 4/4s
Replies: 18
Views: 7121

Re: Exercise EVEN BETTER for 4/4s

I am a bit surprised the studies claim that exercise doesn’t benefit heterozygotic E4s or E3s. I gathered it benefits everyone and helps prevent cognitive decline Hi Chris, Exercise does benefit everyone! It might just provide more of a benefit to people with two copies of ApoE 4/4, because they ar...
by NF52
Tue Sep 20, 2022 6:26 am
Forum: Science and Research
Topic: APOLLOE4 Study: Are you or someone you know struggling with memory loss?
Replies: 10
Views: 2392

Re: APOLLOE4 Study: Are you or someone you know struggling with memory loss?

The August Alzheimer's Association International Conference (AAIC) had a presentation by Alzheon, Inc, referencing benefit to people with ApoE 4 and early stage (mild) AD from the Phase 2 trial of ALZ-801, a pro-drug of tramiprosate. Today a company news release provides specific information on safe...
by NF52
Mon Sep 19, 2022 6:32 pm
Forum: Our Stories
Topic: Will he hide it?
Replies: 4
Views: 152

Re: Will he hide it?

My husband is 3/4 with a strong maternal history of AD (mother and 2 of her male siblings, don't know about older generations). He also has regular phlebotomies for hereditary hemochromatosis (so iron levels are more or less under control); and is at genetic risk for CAD (although he's quite fit, a...
by NF52
Sun Sep 18, 2022 6:23 pm
Forum: Prevention and Treatment
Topic: Hormone replacement therapy - cyclical necessary?
Replies: 2
Views: 133

Re: Hormone replacement therapy - cyclical necessary?

Hello, I am on HRT and taking continuous estrogen. I started with continuous progesterone but then became anxious about the non natural cycle that produces and also I read that Alzheimer is best prevented with cyclical HRT. However, I find I cannot sleep without progesterone. In the days since I on...
by NF52
Fri Sep 16, 2022 5:57 pm
Forum: Science and Research
Topic: Alzheimer's and COVID: Is There a Link?
Replies: 1
Views: 66

Re: Alzheimer's and COVID: Is There a Link?

Older adults with COVID-19 were more likely to have a new diagnosis of Alzheimer's disease a year later than non-infected people, an analysis of electronic medical record (EMR) data showed. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220717 Thanks for sharing this. It's p...
by NF52
Fri Sep 16, 2022 5:09 pm
Forum: Our Stories
Topic: Mom was diagnosed at 71. Am I doomed to younger-onset AD?
Replies: 2
Views: 136

Re: Mom was diagnosed at 71. Am I doomed to younger-onset AD?

Hello again, it's been a while since I've posted thanks to my mom's rapid decline (she was recently diagnosed with multiple myeloma and is now entering middle dementia at just 73 years old). And, as my concerns about her decline grow, so too do my fears about my own future. Recently, I read an arti...