Looks promising?...... Looks intriguing, at the very least! Thanks for finding and sharing this, Greyhound. Below is an excerpt from the open access article https://alzres.biomedcentral.com/articles/10.1186/s13195-022-01020-9]Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and ...

I just read the post that CETP rs5882 G/G is related to long health life and 70% less risk of Alzhiemers! Doing my happy dance! I came to the forum to look up some SNPS and found this. I believe I will just stop for today and enjoy this great news. Thanks to all who help research and post Thanks so...

We started the Bredesen Protocol around July 2019. We have the support of a FM Doctor who happens also to be an MD. My role has been to take the book, and other inputs and interpret where we are in the process while being the best caretaker I can. It's my wife who has the cognitive decline. She is ...

I attended. That's how I found out about this community. :D Welcome 1ofMany! We're glad you found this community! Like you, I found this community after reading of Dr. Bredesen's work and going down lots of other "rabbit holes" of information as someone with two copies of ApoE4. This is a...

APOE ε4 is not associated with increased risk for Alzheimer’s disease and dementia in American Indians I wish they broke up the Native Americans by life style and/or location... Your wish is granted! For some background for others reading this, the current study used multiple cognitive and imaging ...

Hi Kate, another Kate here 😊, and also 4/4. I found out my status too when I was trying to find out if I had a brca mutation. I realised I’d been falsely reassured when I read the small print of the 23andme brca testing, so I paid for testing privately for full brca testing in a clinical genetics l...

And yes, it helps E4s. Further, the researchers noted that an increased intake of DHA might lower risk for developing AD, particularly in higher-risk individuals such as those carrying the APOE-ε4 allele, suggesting that they may benefit more from higher DHA levels than non-carriers. Summary is her...

Ok, thank you very much! I‘ll try to get my doctor to switch to a CCB or ARB instead of the betablockers. Actually now that I think of it my mum started on metoprolol a year ago. I wonder if that has contributed to her memory issues. Best Chris Chris, you said in your post that you are on metoprolo...

Hello kind and knowledgeable fellow ApoE4s, I read through your brilliant material but could not find an answer there. I assume some of you besides myself must be on betablockers for one reason or another (metoprolol for me). I need it for tachycardia, hypertension and migraine prevention. Now it h...

Thanks NF52. Your addition makes it a lot easier to access these articles There are certainly some gold nuggets in the articles, only two are not immediately available. Have you got access to the article from Current Biology titled "Loss of functional heterogeneity along the CA3 transverse axi...