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by NF52
Fri Apr 19, 2024 5:53 pm
Forum: Science and Research
Topic: Nigerian Alzheimer's Paradox?
Replies: 5
Views: 2870

Re: Nigerian Alzheimer's Paradox?

I can't help but wonder if the slowly increasing rate of dementia in the area now is another Weston A. Price (Nutrition and Physical Degeneration) example of western influence polluting traditional diet & lifestyle leading to a deterioration of health. Maybe it's not "low cholesterol,"...
by NF52
Fri Apr 19, 2024 8:32 am
Forum: Prevention and Treatment
Topic: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)
Replies: 130
Views: 285173

Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

. Visit 31 – Week 50 (26th infusion) – UPDATE So, there is one thing I should have mentioned in my last post: Although I stared this journey on September 4, 2022, which was Visit 1A, there was a huge pause in progressing through the remaining various initial requirements. My second visit which was ...
by NF52
Wed Apr 17, 2024 3:37 pm
Forum: Our Stories
Topic: New! 37F apoe3/4 in NYC, Mom (71, apoe3/4) is Pending Alzheimer's Dx
Replies: 22
Views: 6221

Re: New! 37F apoe3/4 in NYC, Mom (71, apoe3/4) is Pending Alzheimer's Dx

. Thank you, Nancy. It was brutal. I'd hoped to be able to slow her decline (in the beginning) to no avail (the family were highly uncooperative and, in fact, worked hard to convince my mom that I didn't know what I was doing). Ultimately, when mom died, the family blamed me for her rapid decline a...
by NF52
Wed Apr 17, 2024 2:23 pm
Forum: Science and Research
Topic: ADMA as Early Warning Sign
Replies: 8
Views: 1097

Re: ADMA as Early Warning Sign

Abstract Background The underlying mechanisms leading to dementia and Alzheimer’s disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.... Hi Plumster, Were ...
by NF52
Wed Apr 17, 2024 2:16 pm
Forum: Our Stories
Topic: New! 37F apoe3/4 in NYC, Mom (71, apoe3/4) is Pending Alzheimer's Dx
Replies: 22
Views: 6221

Re: New! 37F apoe3/4 in NYC, Mom (71, apoe3/4) is Pending Alzheimer's Dx

An update: On July 12, 2023, my beloved mom died at the age of 74 due to rapidly advancing Alzheimer's (she went from stage 4 to 7 in just two years), severe osteoporosis, and multiple myeloma (which was diagnosed in July 2022). Literally no intervention could slow the tide of horror, every 3 month...
by NF52
Tue Apr 16, 2024 9:32 am
Forum: Our Stories
Topic: Long term stories?
Replies: 4
Views: 131

Re: Long term stories?

Hi- I haven't checked in for a long time, and I'm wondering how some of the posters from years ago are doing? I hate to be a downer, but are there some folks out there with long term success and how are they doing now? I would just love some reassurance that there really is hope out there. Thanks i...
by NF52
Sun Apr 14, 2024 5:12 pm
Forum: Prevention and Treatment
Topic: HRT for everyone in RECODE?
Replies: 12
Views: 11966

Re: HRT for everyone in RECODE?

I am an E3/E4 carrier in my 60s on HRT since start of menopause in my mid-50s. I have recently switched from continuous to cyclic (14 days/month) micronized progesterone (oral) with daily transdermal E2 gel. While the studies listed below are mouse models, the idea of cyclic progesterone makes sens...
by NF52
Sat Apr 13, 2024 4:07 pm
Forum: Science and Research
Topic: Good news ApoE4's on cerebral vascular risk in 60's to mid-70's
Replies: 0
Views: 110

Good news ApoE4's on cerebral vascular risk in 60's to mid-70's

This just came out April 9 as an Abstract only on April 9 in Neurology , (which has the catchphrase: "The most widely read and highly cited peer-reviewed neurology journal"). In a study of 194 people, median age 66, with a standard deviation of 10.7 years (so ages 55-77) with normal cognit...
by NF52
Sat Apr 13, 2024 3:40 pm
Forum: Prevention and Treatment
Topic: Let's solve ALZ. APOE4--Nature's/God's Original Design
Replies: 12
Views: 17184

Re: Let's solve ALZ. APOE4--Nature's/God's Original Design

NF52, Is this 2010 Finnish study trying to say their high ALZ rates are a function of (increased/improved) diagnostic reporting? I think it is saying two factors are affecting the prevalence rate: An increasing number of 90+ year olds, which they predicted in 2010 would increase the prevalence (ove...
by NF52
Fri Apr 12, 2024 6:41 pm
Forum: Prevention and Treatment
Topic: Let's solve ALZ. APOE4--Nature's/God's Original Design
Replies: 12
Views: 17184

Re: Let's solve ALZ. APOE4--Nature's/God's Original Design

... (see Finland's own reporting showing exploding ALZ rates over the last 40 years. Where is the critical thinking applied here to explain this disaster? The answer cannot simply be that Finnish people are living significantly longer than they were just 40 years ago or that molds are unique to Fin...