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by Brian4
Fri Nov 05, 2021 5:29 am
Forum: Science and Research
Topic: Ketosis for APOE ε4s
Replies: 14
Views: 711

Re: Ketosis for APOE ε4s

Dr. Bredesen's recommendation to use our KetoFLEX 12/3 diet + long daily fast + daily exercise is for those who are experiencing either insulin resistance or symptoms of cognitive decline with ketosis as a short term goal and restoration of metabolic flexibility as the longer term goal. That said, ...
by Brian4
Wed Nov 03, 2021 6:45 pm
Forum: Science and Research
Topic: Ketosis for APOE ε4s
Replies: 14
Views: 711

Re: Ketosis for APOE ε4s

Hey Tincup, I agree: it wouldn't make sense to question the value of getting one's metabolic house in order. Metabolic syndrome is rare in blue zones. Most of these people eat a lot of carbs, in many cases a huge amount of carbs, but they exercise a lot. There are many paths to healthy metabolism. A...
by Brian4
Wed Nov 03, 2021 10:01 am
Forum: Science and Research
Topic: Ketosis for APOE ε4s
Replies: 14
Views: 711

Re: Ketosis for APOE ε4s

What the studies in this review seem to be saying (collectively) is that people with similar level of ketosis respond similarly regardless of ApoE variants, it just takes longer or more of an intervention to get ApoE4 carriers into ketosis. If so then at least the encouraging news is that if we get...
by Brian4
Tue Nov 02, 2021 1:37 pm
Forum: Announcements and Events
Topic: Soft Launch of Our Metabolomic Project
Replies: 30
Views: 1692

Re: Soft Launch of Our Metabolomic Project

Julie,

This is amazing! Huge thanks to you, Marc, Dr. Cole, Dr. Goodenowe and the people at Prodrome, and everyone else who worked on this. Not only will this help advance some really important science, it will inspire other patient-researcher collaborations.

Brian
by Brian4
Mon Nov 01, 2021 8:17 pm
Forum: Science and Research
Topic: Ketosis for APOE ε4s
Replies: 14
Views: 711

Ketosis for APOE ε4s

Hi everyone, I sort of fell into low-carb eating because carbs were giving me gut problems. Then I discovered I really enjoy eating like a chipmunk. :) I get around 94% of my calories from nuts; the rest, from low-starch veggies (and DHA supplements, which add up, calorie-wise!). And most of the nut...
by Brian4
Sun Sep 12, 2021 2:39 pm
Forum: Prevention and Treatment
Topic: Uric Acid concerns
Replies: 7
Views: 1448

Re: Uric Acid concerns

There is enormous interested in trialing inosine, which raises uric acid levels, as a treatment in several neurological diseases. Inosine does other things, but its effect on uric acid, the most important plasma antioxidant, is thought to be what might drive any benefit. I started looking into inosi...
by Brian4
Wed Sep 08, 2021 7:46 pm
Forum: Announcements and Events
Topic: Gene Therapy Trial for ApoE4 Homozygotes
Replies: 29
Views: 11325

Re: Gene Therapy Trial for ApoE4 Homozygotes

Results from a second generation investigational gene therapy program show effective delivery of APOE2, the gene associated with protection against the development of Alzheimer's disease, while also targeting and silencing APOE4, the gene that increases risk of developing the disease. A 40% reducti...
by Brian4
Tue May 11, 2021 12:54 pm
Forum: Our Stories
Topic: Neurologist's reaction to NeuroQuant results
Replies: 7
Views: 4156

Re: Neurologist's reaction to NeuroQuant results

Hippocampal volume: 12th percentile Hippocampal occupancy: 2nd percentile Inferior lateral ventricles: 96th percentile Dear Seaweed, I hope you got a second opinion, and I hope you got some non-Cowboy care. I've been experiencing some mildly worrying symptoms (which are most likely worsened CFS/ME,...
by Brian4
Sun Jul 19, 2020 7:22 am
Forum: Prevention and Treatment
Topic: Sources of Aluminum in our daily lives, safer alternatives, words to look for on labels
Replies: 59
Views: 20456

Re: Sources of Aluminum in our daily lives, safer alternatives, words to look for on labels

Laurie, thanks so much for the extremely helpful info! As I mentioned before, I'm using ZeroWater, but I take various forms (mostly drops) of supplemental Si throughout the day. The frequent use of Al salts in water treatment facilities is disturbing.... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...
by Brian4
Fri Jul 10, 2020 5:19 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 14660

Re: Using RAPA for AD prevention

I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR r...

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