Search found 224 matches

by Brian4
Fri Jul 12, 2024 4:58 am
Forum: Science and Research
Topic: Meeting Alzheon Executive this week, send your "Burning Questions"
Replies: 5
Views: 311

Re: Meeting Alzheon Executive this week, send your "Burning Questions"

Thanks for the update, June (and for the reminder about AAIC)! Look forward to hearing more when the news becomes available.

With appreciation,
Brian
by Brian4
Tue Jul 09, 2024 5:36 pm
Forum: Science and Research
Topic: Meeting Alzheon Executive this week, send your "Burning Questions"
Replies: 5
Views: 311

Re: Meeting Alzheon Executive this week, send your "Burning Questions"

Thanks, June, and welcome to our group! I would love to know what they think of the structure corrector paper I posted here: https://forums.apoe4.info/viewtopic.php?t=8611 1. Do they think it's likely that ALZ-801 works by altering the conformation of apoE4, as suggested by the above paper? If so, t...
by Brian4
Wed May 29, 2024 6:14 am
Forum: Science and Research
Topic: Peter Attia/ Dr Dena Dubal - Podcast
Replies: 6
Views: 559

Re: Peter Attia/ Dr Dena Dubal - Podcast

Dubal has done great work, but I have never heard her address two recent studies (by the way, among the very few on klotho by people without conflicts of interest...) showing the opposite of what Dubal has claimed about the relation between APOE-ε4 status and benefit from higher klotho levels: https...
by Brian4
Sun May 19, 2024 7:31 pm
Forum: Prevention and Treatment
Topic: suvorexant as a preventative
Replies: 4
Views: 1153

Re: suvorexant as a preventative

Nancy, thanks for the very helpful information! I started suvorexant in late December, not having much hope about its ability to help me sleep, but more intrigued by the amyloid finding. It changed my life. My sleep had deteriorated about fifteen years ago (early-waking insomnia), and suvorexant sol...
by Brian4
Sun May 19, 2024 6:02 am
Forum: Science and Research
Topic: Ketogenic diet induces p53-dependent cellular senescence
Replies: 0
Views: 148

Ketogenic diet induces p53-dependent cellular senescence

The following is a very important study: https://www.science.org/doi/10.1126/sciadv.ado1463 That the mouse component used hydrogenated vegetable shortening can cast doubt on the findings, but the human trial almost certainly did not involve giving the subjects hydrogenatd fatty acids. I'm trying to ...
by Brian4
Wed May 15, 2024 10:48 am
Forum: Science and Research
Topic: Does the protectiveness of APOE 2 cancel the 4, in a 2/4?
Replies: 10
Views: 36273

Re: Does the protectiveness of APOE 2 cancel the 4, in a 2/4?

Welcome Joanna! From what I've read (a lot on this; but not the last couple years' research), 2/4s have a risk for Alzheimer's that is a wee bit lower (better) than 3/4s, but definitely not as good as 3/3s. This is why Lexeo is working on a new treatment that involves increasing apoE2 levels and dec...
by Brian4
Thu Apr 25, 2024 1:20 pm
Forum: Science and Research
Topic: Huge list of therapies / drugs in the pipeline
Replies: 11
Views: 25304

Re: Huge list of therapies / drugs in the pipeline

Hi Fiver. Lexeo is doing an amazing job, and I encourage everyone to support them in whatever way possible. My lament is that they have no compassionate use option -- even for people willing to self-fund, draft a protocol for an IRB, etc. That is what set off the idea of the offshore DIY gene therap...
by Brian4
Thu Apr 25, 2024 6:14 am
Forum: Science and Research
Topic: Huge list of therapies / drugs in the pipeline
Replies: 11
Views: 25304

Re: Huge list of therapies / drugs in the pipeline

Hi Brian, can I ask what you mean about a LX1001 variation?
An effort to create an APOE-ε2 gene therapy very similar to what Lexeo has developed, available off shore, ideally under an ethics board approved trial.
by Brian4
Sun Apr 21, 2024 5:42 am
Forum: Science and Research
Topic: Rapamycin prevents age-related brain vascular deterioration in rats
Replies: 53
Views: 120157

Re: Rapamycin prevents age-related brain vascular deterioration in rats

Rapamycin mimics the effect of calorie restriction, so you can get the benefit with calorie restriction. Some well-done gene expression studies have shown that rapamycin and CR have partly overlapping effects but mostly have quite different effects. This was a big suprise! And a recent study sugges...
by Brian4
Wed Mar 20, 2024 3:05 pm
Forum: Science and Research
Topic: Huge list of therapies / drugs in the pipeline
Replies: 11
Views: 25304

Re: Huge list of therapies / drugs in the pipeline

Thanks LondonGirl. I share your short list. (By the way, some 4/4s are making a variation of LX1001 available off-shore.)

Re BCG: Where can one get this?