I have been unable to figure out or locate any info on the absolute risk. Anyone have info on this? This presentation seems relevant (look at P1-381). https://www.alzheimersanddementia.com/article/S1552-5260(16)31435-2/abstract 9703 subjects followed prospectively. Each characterized by genotype in...

Fiver,

Just tying this abstract in with existing knowledge to draw practical implications.

More background info here:

https://www.physiology.org/doi/10.1152/advan.00052.2006

The abstract states: "PGC-1α overexpression ameliorated ApoE4-induced deficits in glycolysis and mitochondrial respiration." This is useful to know, because PGC-1α expression can be influenced by what we do. Cold exposure, fasting and exercise all tend to increase PGC-1α expression. They m...

Four in the AM three in the PM. I decided to try the multi vitamin that I heard about on this site called ONE. It was the only change I made and wallah!! I have been taking it in the AM and I am waking up only once at night b3M, The fluids taken along with the vitamins in the pm might be sufficient...

The one thing missing, or feeble, in most protocols for preventing Alzheimer's, is emotional well-being. Yet, according to the panel of experts who authored the Lancet article on dementia in 2017, the highest increase in risk for dementia comes from depression. They may or may not be completely accu...

A good counselor will be aware of this useful overview:

https://www.thelancet.com/journals/lanc ... 6/fulltext

Setting up a financial cushion for long-term care makes sense in many ways. We do everything possible to avert cardiovascular disease, Alzheimer's and other conditions. Much is within our control, but not everything. For most people, building a financial cushion will involve setting aside some money...

chrystina3 wrote: I am so thankful that I get to do this.

That is simply beautiful and touching, Chrystina.

Martha, It's normal to feel how you do from time to time. But it's not helpful to pretend that the purpose of life is to avoid Alzheimer's or CVD. Those are worthy aims, but they don't bring the joy and fulfilment that most of us crave. Paradoxically, stressing about getting every last detail of a p...

"A recent study among 5,475 men and 4,580 women aged over 50 showed that a single point increase in negative social support score resulted in a 31 percent rise in the risk of eventual dementia. Negative social support is where you experience a lot of critical, unreliable and annoying behaviors ...