Search found 767 matches

by mike
Fri Sep 16, 2022 2:27 pm
Forum: Science and Research
Topic: Alzheimer's and COVID: Is There a Link?
Replies: 1
Views: 66

Alzheimer's and COVID: Is There a Link?

Older adults with COVID-19 were more likely to have a new diagnosis of Alzheimer's disease a year later than non-infected people, an analysis of electronic medical record (EMR) data showed.
https://content.iospress.com/articles/j ... /jad220717
by mike
Mon Aug 29, 2022 2:39 pm
Forum: Prevention and Treatment
Topic: To HRT or not to HRT
Replies: 5
Views: 334

Re: To HRT or not to HRT

Thank you very much! Yes that does help. As APOE4, I get that HRT in general is beneficial (unless started way too late) but the specifics elude me. I wish there was a doctor anywhere near who is really knowledgeable about this. I am exploring all these other avenues too. I am basically holding a g...
by mike
Mon Aug 29, 2022 12:59 pm
Forum: Our Stories
Topic: Introduction
Replies: 5
Views: 225

Re: Introduction

I was offered the opportunity to have the genetic testing done for free due to there being a "strong history" of AD in my family, but I declined as I don't think that having a definitive "yes" would be good for my wellbeing. For now I am operating with the assumption that I have...
by mike
Wed Aug 17, 2022 10:38 am
Forum: Science and Research
Topic: Keto vs. low-carb Med diet
Replies: 1
Views: 150

Re: Keto vs. low-carb Med diet

as well as being less sustainable
Bah
by mike
Thu Jul 21, 2022 4:07 pm
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 91
Views: 30219

Re: Intermittent Fasting

Here is an article by Stephen Phinney MD PhD & Jeff Volek PhD on the topic. Phinney has been studying this since the late 70's. Scroll down to the heading: The Scientific Details. A quote from the blog, "As shown above, net protein breakdown begins within the first day of fasting, reaches ...
by mike
Thu Jul 21, 2022 12:53 pm
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 91
Views: 30219

Re: Intermittent Fasting

Note that only glycerol in the gluconeogenic substrates comes from fat. No fatty acids are substrates. That is why. The fatty acids can be used to make ketones and the muscles and most of the non cerebral cells (except red blood cells) can use fatty acids for fuel, so use them without any conversio...
by mike
Thu Jul 21, 2022 12:22 pm
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 91
Views: 30219

Re: Intermittent Fasting

Humans can't convert fatty acids back to glucose, we can only burn them in the mitochondria. Some species can, but not humans. I saw it explained more mechanistically here - I hope this clarifies it. This would suggest otherwise. Energy inefficient, but if you need glucose for the brain, still seem...
by mike
Mon Jul 18, 2022 11:45 am
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 91
Views: 30219

Re: Intermittent Fasting

Gluconeogenesis is not only from protein, but primarily from protein. I know this is often assumed, but doesn't make a lot of sense to me - why wouldn't the body make it out of fat reserves...seems like that is what they are for. Can you point to something that proves this? Also gluconeogenesis is ...
by mike
Fri Jul 15, 2022 11:18 am
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 91
Views: 30219

Re: Intermittent Fasting

Your muscles are running on mostly on fat. Your brain is running on a mix of ketones (from the fat metabolism in the liver) and glucose. The glucose is from the glucose you consume as well as converting some of the protein you consume to glucose. There is some glycerol liberated as the fat is metab...