I continue to take rapamycin (Sirolimus). Dr. Green has increased my dose to 8mg a week, although I often still take just 6mg. It's been 14 months now. With anything putting me at risk of infection from its impact on the innate immune system (such as my recent cataract surgery), I temporarily stop i...

Read a New York Times article yesterday about APOE2 gene therapy for 4/4 homozygotes. Since I am one of the admins of the APOE4/4 group on Facebook, I emailed one of the doctors (Dr. Samuel Gandy) last night and he responded this morning, introducing me to the research team at Weill Cornell. Dr. Mic...

4/4 and going on 70 (later this year). Cognitively in great shape. Started rapamycin last November as prescribed by Dr. Alan Green in NY as an AD preventative measure. Feeling wonderful and worrying less these days that I might lose my "marbles". I find that overall, it makes me feel great...

As a 69 year old 4/4 female, I researched the topic of rapamycin extensively, visited with Dr. Green and made the decision 3 months ago, to start rapamycin. I was prescribed 6mg once a week. Started at 4mg/week for one month, and now take 5 mg once a week. Whether I go to 6mg or not remains to be se...

What are thoughts on this study which showed lower triglycerides had higher AD incidence in E4s ? This has me stumped.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860622/

Since coconut oil is not recommended for us (I'm 4/4), i am wondering if I can continue to use it as a moisturizer.....after all, it does get absorbed and into the blood stream....
Thoughts anyone?

Here another very interesting article about BMAA

http://discovermagazine.com/2011/may/22 ... parkinsons

Brian, sorry....I didn't see the question until now. The vibration machine is also called a vibration plate....you stand on it and it sends vibrating pulses through your body. It's the same theory as a chi-machine, which I also have.

I have had a rebounder for years and have started using mine again regularly. It stands to reason that the G-force of jumping continuously for 15 or 20 minutes, which provides a great lymphatic massage would do the same for the brain's lymphatic waste disposal described in this article. https://www....

interesting discussion and one that I'm sure we all have very individual thoughts about. Being able to leave this existence on my own terms is far more comforting than the idea of spending years in a vegetative state not knowing the faces of my 4 beautiful children, my dear husband, my grandchildren...