Search found 299 matches

by BrianR
Sun Apr 07, 2024 8:08 am
Forum: Science and Research
Topic: Article: APOE loss of function: A genetic shield against Alzheimer’s disease
Replies: 1
Views: 27445

Article: APOE loss of function: A genetic shield against Alzheimer’s disease

This study finds [not surprisingly] that a loss of function in an APOE ε4 allele can provide resistance to Alzheimer’s disease. Note that this loss of function is apparently very rare "in the wild" and only seven individuals with various APOE mutations were analyzed. The paper asserts that...
by BrianR
Mon Feb 12, 2024 7:11 pm
Forum: Science and Research
Topic: Paper: Translational approaches to understanding resilience to Alzheimer’s disease
Replies: 2
Views: 11429

Paper: Translational approaches to understanding resilience to Alzheimer’s disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035083/ Translational approaches to understanding resilience to Alzheimer's disease. Neuner SM, Telpoukhovskaia M, Menon V, O'Connell KMS, Hohman TJ, Kaczorowski CC. Trends Neurosci. 2022 May;45(5):369-383. doi: 10.1016/j.tins.2022.02.005. Epub 2022 Mar...
by BrianR
Sun Nov 19, 2023 7:44 am
Forum: Prevention and Treatment
Topic: The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mi
Replies: 2
Views: 2241

Re: The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgeni

Did I miss the link? It's this paper, right? The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice. Martinsen A, Saleh RNM, Chouinard-Watkins R, Bazinet R, Harden G, Dick J, Tejera N, Pontifex MG, Vauzour D, Minihane AM. Nutrients....
by BrianR
Sun Oct 08, 2023 7:42 am
Forum: Science and Research
Topic: High HDL risk factor for AD
Replies: 8
Views: 27969

Re: High HDL risk factor for AD

Oh No! Man the risk factors keep coming. My HDL runs between 82mg/dl and 95mg/dl. I guess giving up my daily half avocado, Evo, oily fish and exercise is not a plan :lol: You might want to listen to this podcast to get an excessively better understanding of HDL, to the extent it's understood. #240 ...
by BrianR
Wed Jul 12, 2023 8:39 pm
Forum: Science and Research
Topic: Kellyann Niotis talk: Preventive Neurology: Targeting ApoE4 to Combat Alzheimer's Disease
Replies: 2
Views: 1763

Kellyann Niotis talk: Preventive Neurology: Targeting ApoE4 to Combat Alzheimer's Disease

Another lipid.org journal club talk, this one by Kellyann Niotis (formerly of Cornell Weill): https://www.lipid.org/media/journalclub/selaspeaks04/ This presentation has some overlap with the Thomas Dayspring talk, but doesn't tend to go as deep and focuses more on APOE4 topics of interest. (IMO). R...
by BrianR
Wed Jul 12, 2023 7:59 pm
Forum: Science and Research
Topic: Thomas Dayspring talk: ApoE in the Periphery and in the Brain
Replies: 10
Views: 7036

Thomas Dayspring talk: ApoE in the Periphery and in the Brain

Dayspring talk for Lipidologists: https://www.lipid.org/media/journalclub/selaspeaks03/hotfix.html Or you can go to lipid.org journal club page and look for the talk ApoE - What Lipidologists Need to Know and What They Were Never Taught Presented by Thomas Dayspring, MD, FACP, FNLA and moderated by ...
by BrianR
Fri Jun 23, 2023 6:42 am
Forum: Science and Research
Topic: Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease
Replies: 0
Views: 1000

Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease

An open access "comprehensive review of the therapeutic potential of incretin mimetics and insulin in [Alzheimer’s disease and Parkinson’s disease]." https://www.nature.com/articles/s41380-022-01792-4 Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson...
by BrianR
Fri May 26, 2023 1:23 pm
Forum: Prevention and Treatment
Topic: Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases
Replies: 1
Views: 1366

Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases

Note that this study (preprint) doesn't address why a shingles (herpes zoster) vaccination might prevent dementia, but does provide an interesting look at dementia incidence in two very similar populations, differentiated by date of birth. (Which was an eligibility criterion for receiving the shingl...
by BrianR
Sat May 13, 2023 7:31 am
Forum: Science and Research
Topic: Very Good Peter Attia podcast
Replies: 16
Views: 11575

Re: Very Good Peter Attia podcast

But, I can say that my dad (who is 83 and is significantly starting to decline cognitively) lost his sense of smell and taste over 10 years ago. I had no idea that there was a possible connection. My father lost much of his sense of smell and taste in his early fifties. Now 90, he definitely has co...