Open access. Three year study with moderate sized population. https://www.frontiersin.org/articles/10.3389/fnagi.2022.927656/pdf Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia Tung Hsin, Lin Ching-Heng, Chen Yi-Ming, Lee Wei-Ju, Chien Li...

... but I’ve read that statins shouldn’t be taken if you have a APOE4 marker. For what it's worth, Peter Attia uses blood plasma levels of desmosterol as an indicator of whether statins might be adversely affecting brain lipid levels in his patients: From a clinical perspective, low desmosterol lev...

I quoted one of those articles noting brain shrinkage in the Lecanamab: Efficacy, Side Effects, and More thread. This is concerning given that brain shrinkage is associated with dementia and we don't know long term effects of these drugs yet. Thanks Theresa, I had forgotten that. Excellent question...

Two very readable opinion pieces touching on evidence that anti-amyloid antibody treatments may exacerbate brain shrinkage. The summary is that this apparent phenomenon ought to be better understood before widespread use of these drugs (e.g. lecanemab). Derek Lowe blog (motivated by the Stat article...

Open access review paper. I found it to be more clearly written than similarly detailed APOE-related papers. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00574-4 ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies Ana-Caroline Raulin, Sydney V....

I know some members here have hypermobility issues. I thought I'd bring this August pre-print to your attention: Folate-Deficient Hypermobility Syndrome I liked this article. "Hypermobility syndrome [has a] suggested prevalence of 2-57% of the population" suggests that additional science ...

Open access review on APOE and neurodegenerative diseases. Or, as one of the authors tweeted: "OUR BIBLE OF APOE IS OUT!" https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00566-4 APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype...

I liked this interview with Jeff Iliff which discussed his work on the glymphatic system and how it may interact with various concerns, including Alzheimer's. STEM-Talk Episode 141: Jeff Iliff on newly discovered system that clears waste from the brain The technical details start at about 16 minutes...

... Also, what % of people die before age 73? It looks like you're saying that 2/3 of 4/4 native americans die before age 73 (.7/2)? Seems a bit high... Source: https://www.ihs.gov/newsroom/factsheets/disparities/ American Indians and Alaska Natives born today have a life expectancy that is 5.5 yea...

Open access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066743/ Alzheimer's disease drug development pipeline: 2022 Jeffrey Cummings,corresponding author, Garam Lee, Pouyan Nahed, Mina Esmail Zadeh Nojoo Kambar, Kate Zhong, Jorge Fonseca, and Kazem Taghva Alzheimers Dement (N Y). 2022; 8(1): e122...