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by BrianR
Fri Nov 12, 2021 4:58 pm
Forum: Science and Research
Topic: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?
Replies: 5
Views: 964

Re: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?

Brian is a great, smart guy--but I think he's a good bit younger than this grandmother of two! NF52, your assessment is very generous :) As for the age thing, well my younger brother is a grandfather of three. But at least I still have a few months before I need to sign up for Medicare ... (And I a...
by BrianR
Mon Oct 11, 2021 12:07 pm
Forum: Science and Research
Topic: Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?
Replies: 5
Views: 964

Can an Already Approved Drug [bumetanide] Treat Alzheimer’s Disease?

Assuming they can establish a meaningful RCT, it will be interesting to see clinical results in humans. Article: https://gladstone.org/news/can-already-approved-drug-treat-alzheimers-disease Researchers at Gladstone Institutes teamed up with scientists from UC San Francisco (UCSF) and Icahn School o...
by BrianR
Sat Oct 09, 2021 7:49 am
Forum: Prevention and Treatment
Topic: Hack for falling back asleep in middle of the night
Replies: 10
Views: 1591

Re: Hack for falling back asleep in middle of the night

This approach worked well for me to get back to sleep after several middle of the night ruminations.. Well, I was skeptical, but after trying it, I have to join the crowd and report that this technique has worked amazingly well for me. Thanks for posting it. (As an alternative for some, my sister s...
by BrianR
Mon Oct 04, 2021 6:47 am
Forum: Prevention and Treatment
Topic: OT: LCHF diet and the gut
Replies: 1
Views: 686

OT: LCHF diet and the gut

The gut - it's more complicated than you think. And don't rely on mouse studies for your diet advice. I thought this STEM-Talk podcast with Tommy Woods was interesting: Episode 128: Tommy Wood talks about high-fat diets and the metabolic flexibility of the human gut They discuss the findings of this...
by BrianR
Tue Sep 28, 2021 4:26 pm
Forum: Science and Research
Topic: Peter Attia: Statins, Dementia, Desmosterol
Replies: 0
Views: 649

Peter Attia: Statins, Dementia, Desmosterol

Peter Attia's most recent weekly note discussion brain cholesterol, statins and desmosterol. Does low cholesterol cause cognitive impairment? Part II One of the most common causes of reduced desmosterol is statin therapy. Statins can cross the BBB — and while the data is conflicting — a recent study...
by BrianR
Tue Sep 28, 2021 4:21 pm
Forum: Science and Research
Topic: Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity
Replies: 0
Views: 572

Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity

I learned that there exists a sub-type of AD patients who have "silent" epileptic activity in their brains. And that the epilepsy drug Levetiracetam is beneficial in improving their AD symptoms. I guess time will tell if this is just a "duh ..." kind of thing, where the epilepsy ...
by BrianR
Tue Sep 14, 2021 3:37 pm
Forum: Science and Research
Topic: Thrombotic - Fibrinolytic Balance and ASCVD events
Replies: 1
Views: 272

Thrombotic - Fibrinolytic Balance and ASCVD events

Paywalled paper: https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehab600/6368900?redirectedFrom=fulltext Atherothrombotic factors and atherosclerotic cardiovascular events: the multi-ethnic study of atherosclerosis Andrew P DeFilippis, Patrick J Trainor, George Than...
by BrianR
Fri Sep 10, 2021 3:58 pm
Forum: Science and Research
Topic: APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Replies: 3
Views: 429

Re: APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolys

SusanJ wrote:My first take is that there must be some reproductive advantage for E4 females to have this decreased resting energy expenditure.

Perhaps. Or maybe other advantages offered by APOE4 (enhanced immune activity against parasites?) made up for the side effects.
by BrianR
Wed Sep 08, 2021 5:29 pm
Forum: Science and Research
Topic: APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Replies: 3
Views: 429

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Open access: https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-021-00483-y APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis Molecular Neurodegeneration volume 16, Article number: 62 (2021) [published 6 S...
by BrianR
Wed Sep 08, 2021 5:22 pm
Forum: Science and Research
Topic: A GWAS Study identifies new risk loci for Alzheimer’s disease
Replies: 1
Views: 287

A GWAS Study identifies new risk loci for Alzheimer’s disease

A brief summary. Open access: https://www.nature.com/articles/s41588-021-00921-z.epdf?sharing_token=4akiS2tGVg92pQL1K6H9JNRgN0jAjWel9jnR3ZoTv0Mp8QR0zYEql-oZczk4yfLdXRZVexLAmVmKckOA5AYJm4XlK5vpwVqu9ffoEHjJsppUxdoc9cKSg_5YMvMP8ih1gMbjMThbubmUKRx52ZPBM7S3HzrBRnawzOwrUfd9oCw%3D A genome-wide association...

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