Search found 299 matches
- Sun Apr 07, 2024 8:08 am
- Forum: Science and Research
- Topic: Article: APOE loss of function: A genetic shield against Alzheimer’s disease
- Replies: 1
- Views: 22226
Article: APOE loss of function: A genetic shield against Alzheimer’s disease
This study finds [not surprisingly] that a loss of function in an APOE ε4 allele can provide resistance to Alzheimer’s disease. Note that this loss of function is apparently very rare "in the wild" and only seven individuals with various APOE mutations were analyzed. The paper asserts that...
- Mon Feb 12, 2024 7:11 pm
- Forum: Science and Research
- Topic: Paper: Translational approaches to understanding resilience to Alzheimer’s disease
- Replies: 2
- Views: 9375
Paper: Translational approaches to understanding resilience to Alzheimer’s disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035083/ Translational approaches to understanding resilience to Alzheimer's disease. Neuner SM, Telpoukhovskaia M, Menon V, O'Connell KMS, Hohman TJ, Kaczorowski CC. Trends Neurosci. 2022 May;45(5):369-383. doi: 10.1016/j.tins.2022.02.005. Epub 2022 Mar...
- Sun Nov 19, 2023 7:44 am
- Forum: Prevention and Treatment
- Topic: The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mi
- Replies: 2
- Views: 2152
Re: The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgeni
Did I miss the link? It's this paper, right? The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice. Martinsen A, Saleh RNM, Chouinard-Watkins R, Bazinet R, Harden G, Dick J, Tejera N, Pontifex MG, Vauzour D, Minihane AM. Nutrients....
- Sun Oct 08, 2023 7:42 am
- Forum: Science and Research
- Topic: High HDL risk factor for AD
- Replies: 8
- Views: 27806
Re: High HDL risk factor for AD
Oh No! Man the risk factors keep coming. My HDL runs between 82mg/dl and 95mg/dl. I guess giving up my daily half avocado, Evo, oily fish and exercise is not a plan :lol: You might want to listen to this podcast to get an excessively better understanding of HDL, to the extent it's understood. #240 ...
- Thu Jul 13, 2023 4:26 pm
- Forum: Science and Research
- Topic: Kellyann Niotis talk: Preventive Neurology: Targeting ApoE4 to Combat Alzheimer's Disease
- Replies: 2
- Views: 1647
- Wed Jul 12, 2023 8:39 pm
- Forum: Science and Research
- Topic: Kellyann Niotis talk: Preventive Neurology: Targeting ApoE4 to Combat Alzheimer's Disease
- Replies: 2
- Views: 1647
Kellyann Niotis talk: Preventive Neurology: Targeting ApoE4 to Combat Alzheimer's Disease
Another lipid.org journal club talk, this one by Kellyann Niotis (formerly of Cornell Weill): https://www.lipid.org/media/journalclub/selaspeaks04/ This presentation has some overlap with the Thomas Dayspring talk, but doesn't tend to go as deep and focuses more on APOE4 topics of interest. (IMO). R...
- Wed Jul 12, 2023 7:59 pm
- Forum: Science and Research
- Topic: Thomas Dayspring talk: ApoE in the Periphery and in the Brain
- Replies: 10
- Views: 6883
Thomas Dayspring talk: ApoE in the Periphery and in the Brain
Dayspring talk for Lipidologists: https://www.lipid.org/media/journalclub/selaspeaks03/hotfix.html Or you can go to lipid.org journal club page and look for the talk ApoE - What Lipidologists Need to Know and What They Were Never Taught Presented by Thomas Dayspring, MD, FACP, FNLA and moderated by ...
- Fri Jun 23, 2023 6:42 am
- Forum: Science and Research
- Topic: Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease
- Replies: 0
- Views: 901
Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease
An open access "comprehensive review of the therapeutic potential of incretin mimetics and insulin in [Alzheimer’s disease and Parkinson’s disease]." https://www.nature.com/articles/s41380-022-01792-4 Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson...
- Fri May 26, 2023 1:23 pm
- Forum: Prevention and Treatment
- Topic: Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases
- Replies: 1
- Views: 1320
Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases
Note that this study (preprint) doesn't address why a shingles (herpes zoster) vaccination might prevent dementia, but does provide an interesting look at dementia incidence in two very similar populations, differentiated by date of birth. (Which was an eligibility criterion for receiving the shingl...
- Sat May 13, 2023 7:31 am
- Forum: Science and Research
- Topic: Very Good Peter Attia podcast
- Replies: 16
- Views: 11398
Re: Very Good Peter Attia podcast
But, I can say that my dad (who is 83 and is significantly starting to decline cognitively) lost his sense of smell and taste over 10 years ago. I had no idea that there was a possible connection. My father lost much of his sense of smell and taste in his early fifties. Now 90, he definitely has co...