Search found 274 matches

by BrianR
Mon Jun 20, 2022 12:03 pm
Forum: Science and Research
Topic: When did ApoE3 first arise?
Replies: 15
Views: 390

Re: When did ApoE3 first arise?

Hi Mike, you might take some of the timetable inferences from genetic drift (as opposed to specific ancient dna evidence) a little skeptically. See, e.g., a couple of recent review/commentaries from Razib regarding new papers suggesting reinterpretations of population splits. It seems like the scie...
by BrianR
Sun Jun 19, 2022 6:24 pm
Forum: Science and Research
Topic: Review: A multi-hit hypothesis for an APOE4-dependent pathophysiological state
Replies: 4
Views: 226

Review: A multi-hit hypothesis for an APOE4-dependent pathophysiological state

Open access. A review which discusses 9 methods ( hits ) by which APOE4 can damage brains. Extensive references if you want to dig deeper into any of those methods. ( neurodegeneration, neurovascular dysfunction, neuroinflammation, oxidative stress, endosomal trafficking impairments, lipid and cellu...
by BrianR
Fri May 13, 2022 5:02 pm
Forum: Science and Research
Topic: Study identifies biomarkers that could guide precision medicine therapies for Alzheimer's disease
Replies: 3
Views: 256

Re: Study identifies biomarkers that could guide precision medicine therapies for Alzheimer's disease

Greyhound, I could not find the specific biomarkers that this study identified. I pulled up the link and it did not list the biomarkers either. I wonder if these biomarkers correlate with the biomarkers Bredesen follows? Thank you for the posting! Gail, I quickly skimmed the paper https://alz-journ...
by BrianR
Mon May 02, 2022 10:02 am
Forum: Science and Research
Topic: APOE-ε4 and brain iron (ferritin) levels paper
Replies: 1
Views: 276

APOE-ε4 and brain iron (ferritin) levels paper

Open access paper explores a mechanism by which APOE4 may contribute to AD. https://www.nature.com/articles/s41380-022-01568-w Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy Abdel Ali Belaidi, Shashank Masaldan, Adam Southon, Pawel Kalinowski, Karla Acevedo, Ambili T. Appu...
by BrianR
Sat Apr 23, 2022 8:26 am
Forum: Science and Research
Topic: Somewhat OT: Endemic Pathogens Are Making You Crazy And Then Killing You
Replies: 3
Views: 239

Somewhat OT: Endemic Pathogens Are Making You Crazy And Then Killing You

The author touches on several types of endemic infections that are correlated with AD, but otherwise focuses on other very successful long-term microbial pathogens - particularly Toxoplasma Gondii. I thought it was a interesting summary of a bunch of different types of very common infections we'd be...
by BrianR
Sat Mar 19, 2022 8:33 pm
Forum: Science and Research
Topic: Research observations & snippets from AD/PD 2022 International Conference on Alzheimer's and Parkinson's Diseases...
Replies: 0
Views: 155

Research observations & snippets from AD/PD 2022 International Conference on Alzheimer's and Parkinson's Diseases...

AD/PD™ 2022​ brings a new look and a new chapter in the history of the AD/PD™ series of conferences. By merging together with the AAT-AD/PD™ Advances in Alzheimer’s Therapies Focus Meeting, AD/PD™ is now transformed into an annual meeting, with a continuing focus on the ADVANCES IN SCIENCE & TH...
by BrianR
Fri Mar 18, 2022 4:53 pm
Forum: Science and Research
Topic: 2020 Deep Dive into Statins with Roberta Brinton et al
Replies: 15
Views: 1477

Re: 2020 Deep Dive into Statins with Roberta Brinton et al

You may find Peter Attia's two newsletters on "Does low cholesterol cause cognitive impairment?" useful, particularly part 2 in which he discusses plasma desmosterol level as a potential indicator for statin use increasing the possibility of AD. Does low cholesterol cause cognitive impairm...
by BrianR
Sat Mar 05, 2022 11:11 am
Forum: Science and Research
Topic: APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia
Replies: 0
Views: 234

APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia

Preprint. Mouse model. Confirms Brian's biases. https://www.biorxiv.org/content/10.1101/2022.03.01.480612v1 APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell do...
by BrianR
Sat Feb 26, 2022 5:21 pm
Forum: Science and Research
Topic: APOE genotyping: more complex than my old 23andme summary suggested
Replies: 17
Views: 927

Re: APOE genotyping: more complex than my old 23andme summary suggested

Wow! You made my day! The evidence continues to build that there's no more point in paying attention to science, so maybe I'll find a tetherball somewhere :lol: :lol: Of course, skepticism is an important part of the scientific process. And we'd all really like it if dementia had, exclusively, simp...
by BrianR
Sun Feb 20, 2022 1:22 pm
Forum: Science and Research
Topic: APOE genotyping: more complex than my old 23andme summary suggested
Replies: 17
Views: 927

APOE genotyping: more complex than my old 23andme summary suggested

Open access. Interesting for those who want to assess risk based on SNPs and, perhaps, those who want to worry less based on past genetic testing maybe not reflecting actual risks. https://alzres.biomedcentral.com/articles/10.1186/s13195-022-00962-4 Challenges at the APOE locus: a robust quality con...