Search found 284 matches

by BrianR
Tue Dec 27, 2022 9:28 am
Forum: Science and Research
Topic: Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia
Replies: 0
Views: 108

Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia

Open access. Three year study with moderate sized population. https://www.frontiersin.org/articles/10.3389/fnagi.2022.927656/pdf Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia Tung Hsin, Lin Ching-Heng, Chen Yi-Ming, Lee Wei-Ju, Chien Li...
by BrianR
Fri Dec 23, 2022 5:13 pm
Forum: Our Stories
Topic: Using statins with APOE 3/4 genetics
Replies: 6
Views: 821

Re: Using statins with APOE 3/4 genetics

... but I’ve read that statins shouldn’t be taken if you have a APOE4 marker. For what it's worth, Peter Attia uses blood plasma levels of desmosterol as an indicator of whether statins might be adversely affecting brain lipid levels in his patients: From a clinical perspective, low desmosterol lev...
by BrianR
Fri Dec 16, 2022 12:54 pm
Forum: Science and Research
Topic: Anti-amyloid antibody drugs and brain shrinkage
Replies: 3
Views: 236

Re: Anti-amyloid antibody drugs and brain shrinkage

I quoted one of those articles noting brain shrinkage in the Lecanamab: Efficacy, Side Effects, and More thread. This is concerning given that brain shrinkage is associated with dementia and we don't know long term effects of these drugs yet. Thanks Theresa, I had forgotten that. Excellent question...
by BrianR
Sun Dec 11, 2022 8:26 am
Forum: Science and Research
Topic: Anti-amyloid antibody drugs and brain shrinkage
Replies: 3
Views: 236

Anti-amyloid antibody drugs and brain shrinkage

Two very readable opinion pieces touching on evidence that anti-amyloid antibody treatments may exacerbate brain shrinkage. The summary is that this apparent phenomenon ought to be better understood before widespread use of these drugs (e.g. lecanemab). Derek Lowe blog (motivated by the Stat article...
by BrianR
Fri Nov 11, 2022 6:04 am
Forum: Science and Research
Topic: Review: ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
Replies: 0
Views: 151

Review: ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Open access review paper. I found it to be more clearly written than similarly detailed APOE-related papers. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00574-4 ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies Ana-Caroline Raulin, Sydney V....
by BrianR
Wed Sep 28, 2022 6:37 am
Forum: The Social Hour
Topic: Folate-Deficient Hypermobility Syndrome
Replies: 2
Views: 520

Re: Folate-Deficient Hypermobility Syndrome

I know some members here have hypermobility issues. I thought I'd bring this August pre-print to your attention: Folate-Deficient Hypermobility Syndrome I liked this article. "Hypermobility syndrome [has a] suggested prevalence of 2-57% of the population" suggests that additional science ...
by BrianR
Wed Sep 28, 2022 6:22 am
Forum: Science and Research
Topic: APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and ...
Replies: 0
Views: 150

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and ...

Open access review on APOE and neurodegenerative diseases. Or, as one of the authors tweeted: "OUR BIBLE OF APOE IS OUT!" https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-022-00566-4 APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype...
by BrianR
Fri Sep 09, 2022 11:03 am
Forum: Science and Research
Topic: Podcast: Jeff Iliff on the glymphatic system
Replies: 1
Views: 115

Podcast: Jeff Iliff on the glymphatic system

I liked this interview with Jeff Iliff which discussed his work on the glymphatic system and how it may interact with various concerns, including Alzheimer's. STEM-Talk Episode 141: Jeff Iliff on newly discovered system that clears waste from the brain The technical details start at about 16 minutes...
by BrianR
Sun Jul 03, 2022 7:07 am
Forum: Science and Research
Topic: Review: A multi-hit hypothesis for an APOE4-dependent pathophysiological state
Replies: 5
Views: 406

Re: Review: A multi-hit hypothesis for an APOE4-dependent pathophysiological state

... Also, what % of people die before age 73? It looks like you're saying that 2/3 of 4/4 native americans die before age 73 (.7/2)? Seems a bit high... Source: https://www.ihs.gov/newsroom/factsheets/disparities/ American Indians and Alaska Natives born today have a life expectancy that is 5.5 yea...
by BrianR
Sun Jul 03, 2022 7:02 am
Forum: Science and Research
Topic: Alzheimer's disease drug development pipeline: 2022
Replies: 3
Views: 268

Alzheimer's disease drug development pipeline: 2022

Open access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066743/ Alzheimer's disease drug development pipeline: 2022 Jeffrey Cummings,corresponding author, Garam Lee, Pouyan Nahed, Mina Esmail Zadeh Nojoo Kambar, Kate Zhong, Jorge Fonseca, and Kazem Taghva Alzheimers Dement (N Y). 2022; 8(1): e122...