Yes, I goofed.

Another lipid.org journal club talk, this one by Kellyann Niotis (formerly of Cornell Weill): https://www.lipid.org/media/journalclub/selaspeaks04/ This presentation has some overlap with the Thomas Dayspring talk, but doesn't tend to go as deep and focuses more on APOE4 topics of interest. (IMO). R...

Dayspring talk for Lipidologists: https://www.lipid.org/media/journalclub/selaspeaks03/hotfix.html Or you can go to lipid.org journal club page and look for the talk ApoE - What Lipidologists Need to Know and What They Were Never Taught Presented by Thomas Dayspring, MD, FACP, FNLA and moderated by ...

An open access "comprehensive review of the therapeutic potential of incretin mimetics and insulin in [Alzheimer’s disease and Parkinson’s disease]." https://www.nature.com/articles/s41380-022-01792-4 Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson...

Note that this study (preprint) doesn't address why a shingles (herpes zoster) vaccination might prevent dementia, but does provide an interesting look at dementia incidence in two very similar populations, differentiated by date of birth. (Which was an eligibility criterion for receiving the shingl...

But, I can say that my dad (who is 83 and is significantly starting to decline cognitively) lost his sense of smell and taste over 10 years ago. I had no idea that there was a possible connection. My father lost much of his sense of smell and taste in his early fifties. Now 90, he definitely has co...

Open access. Review article inspired by the October 2021 Alzheimer's Association's APOE and Immunity virtual conference. https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13020 APOE and immunity: Research highlights Courtney M. Kloske, et al. Alzheimer’s & Dementia First publishe...

For those who are very interested in lipids. From Thomas Dayspring " Illustration of INDIRECT Reverse Cholesterol Transport where HDL acquires cellular cholesterol, esterifies it to cholesteryl ester & then using CETP, transfers CE to LDL which delivers the CE to the liver: returning CE to ...

Rather than cluttering up @alantisw's post, I'll add this related information separately. Thomas Dayspring recommended this bit of research description from New Amsterdam Pharmaceuticals which provides an overview of their CETP inhibitor Obicetrapib. To save you a trip to their fancy web site, here ...

Fascinated by this, I felt we needed a new ApoE4.info wiki on this subject, it can be found here: From Fructose to Alzheimer's . I tried to keep the discussion high level and accessible, but there's so much to this subject, I hope I did it justice. ... Theresa, this is a superb addition to the wiki...