Search found 2499 matches

by SusanJ
Thu Dec 01, 2022 8:34 pm
Forum: Prevention and Treatment
Topic: Request for thoughts on treating depression. Depression is linked to dementia, but anti-depression drugs are too
Replies: 4
Views: 144

Re: Request for thoughts on treating depression. Depression is linked to dementia, but anti-depression drugs are too

Cognitive Behavioral Therapy (CBT) seems to be a good place to start for most people. The cognitive and behavioral interventions (if adequately implemented) can be as efficacious as medications in the treatment of even more severe depression (DeRubeis et al., 2005; Dimidjian et al., 2006) and have a...
by SusanJ
Sun Nov 13, 2022 9:01 am
Forum: Prevention and Treatment
Topic: Still so worried about sleep
Replies: 16
Views: 753

Re: Still so worried about sleep

So I will try to get a doctor to explain the blood sugar. Not every general doctor will understand what's going on. Two things to for you to look at, the dawn phenomenon and the Somogyi effect. This article from WebMd is aimed at diabetics, but has some basic information about the difference betwee...
by SusanJ
Tue Nov 01, 2022 8:44 am
Forum: Science and Research
Topic: Newly discovered protein connected to Alzheimer’s disease risk
Replies: 6
Views: 394

Re: Newly discovered protein connected to Alzheimer’s disease risk

However, 23andMe is only showing one result, ie, one A without showing what the paired result is. Maybe mtDNA isn't paired the same way, or doesn't produce heterozygous results, so they only report one result? Here's your answer about pairing, from Wikipedia: The two strands of the human mitochondr...
by SusanJ
Sun Oct 30, 2022 11:49 am
Forum: Science and Research
Topic: Newly discovered protein connected to Alzheimer’s disease risk
Replies: 6
Views: 394

Re: Newly discovered protein connected to Alzheimer’s disease risk

Plumster wrote:How do you think it would be given as an analog?
That's way beyond my pay grade.

I'm mostly interested because this group is looking at something other than amyloid beta or tau as a target for treatment.
by SusanJ
Sat Oct 29, 2022 9:31 am
Forum: Science and Research
Topic: Newly discovered protein connected to Alzheimer’s disease risk
Replies: 6
Views: 394

Re: Newly discovered protein connected to Alzheimer’s disease risk

Here's another article about SHMOOSE from Being Patient. https://www.beingpatient.com/shmoose-in-the-news-influential-new-alzheimers-gene-discovered/ With its connection to mitochondrial function, this seems like one that could lead to treatments to overcome brain energy metabolism problems. Feels l...
by SusanJ
Thu Oct 13, 2022 9:44 pm
Forum: Prevention and Treatment
Topic: carrying a lighter mental load
Replies: 8
Views: 376

Re: carrying a lighter mental load

Thank you for any suggestions. When I had to do some deeper work, I found the idea of "morning pages" useful. You just sit first thing in the morning and write 3 pages of whatever comes to mind to fill 3 pages. Long hand works best for me, because it slows me down. And sometimes you just ...
by SusanJ
Thu Oct 13, 2022 9:31 pm
Forum: Prevention and Treatment
Topic: too much olive oil?
Replies: 14
Views: 589

Re: too much olive oil?

Here is the question: is this ok? I'm one of those who can't keep on weight with a high fat diet. I do agree with NF52 that you could use more protein. Because you are eating some carbs, you might be okay with your current g/day there. I now personally shoot for 75 g of protein and 125 g of net car...
by SusanJ
Wed Oct 12, 2022 11:55 am
Forum: Science and Research
Topic: New Antioxidant Can Prevent MI & Stroke
Replies: 1
Views: 189

Re: New Antioxidant Can Prevent MI & Stroke

Will be interested in watching for the human trials. Professor David Leake, BHF-funded researcher who led the study at the University of Reading, said: “The potential in this drug to protect against heart attacks and strokes and ultimately save lives superseded our expectations. We hoped it would ca...
by SusanJ
Wed Oct 12, 2022 11:40 am
Forum: Prevention and Treatment
Topic: Hormone Replacement Therapy E4 Women
Replies: 746
Views: 282106

Re: Hormone Replacement Therapy E4 Women

Interesting mouse study, finding that E4/E4 mice did not get improvement in object and spatial memory, or increased neuron dendritic spine density when given estradiol, while they did see improvements in E3/E4 and E3/E3 mice. They surmise it is related to the increased number of alpha estrogen recep...
by SusanJ
Wed Oct 05, 2022 10:18 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1228
Views: 118412

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Have you seen Greyhound's post about soluble amyloid and the comment on lecanemab? Might be the reason why they are seeing success.

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