Search found 5503 matches

by circular
Mon Dec 05, 2022 11:30 am
Forum: Prevention and Treatment
Topic: Sleep
Replies: 4
Views: 143

Re: Sleep

Tincup wrote: Sun Dec 04, 2022 6:19 am I find listening to Yoga Nidra scripts (also known as NSDR or non sleep deep rest) work very well.
I second Yoga Nidra, of course YMMV.
by circular
Thu Nov 24, 2022 6:05 pm
Forum: Science and Research
Topic: aricept
Replies: 4
Views: 328

Re: aricept

MMSE is a helpful tool, but has limitations. It is a 30-point questionnaire that only takes between 5 and 10 minutes. From Mini-Mental State Examination the most frequently noted disadvantage of the MMSE relates to its lack of sensitivity to mild cognitive impairment and its failure to adequately d...
by circular
Thu Nov 24, 2022 9:04 am
Forum: Science and Research
Topic: Ayurvedic Profiling of Alzheimer's Disease (Bredesen and Rao, 2017
Replies: 0
Views: 73

Ayurvedic Profiling of Alzheimer's Disease (Bredesen and Rao, 2017

This abstract came up at PubMed, but there's no link there to the paper itself or even the journal. I searched the forum for the title and that didn't come up. Can anyone share a copy here, assuming Drs. Bredesen and Rao are okay with that. Otherwise I can email them. I'm just not sure how long it w...
by circular
Fri Nov 18, 2022 10:30 am
Forum: The Social Hour
Topic: Welcome Brother Chris!
Replies: 2
Views: 162

Re: Welcome Brother Chris!

Chris Hemsworth just learned that he's an ApoE4/4. Guided by Peter Attia, he's proactively taking control of his health. What an amazing role model for his generation! Read more here. His story, in broad strokes, made it onto CNN's home page today https://www.cnn.com/2022/11/17/entertainment/chris-...
by circular
Sun Oct 30, 2022 5:00 pm
Forum: Science and Research
Topic: Newly discovered protein connected to Alzheimer’s disease risk
Replies: 6
Views: 396

Re: Newly discovered protein connected to Alzheimer’s disease risk

I'm giving myself a little pat on the back, because for years, since before this forum, I've had a strong hunch that mtDNA would be involved in Alzheimer's, and I could never understand why it doesn't came up as a research subtopic anywhere. My mother and I have the A allele and are mtDNA haplogroup...
by circular
Sat Oct 22, 2022 1:58 pm
Forum: Prevention and Treatment
Topic: carrying a lighter mental load
Replies: 8
Views: 377

Re: carrying a lighter mental load

Dr. Bredesen recently posted this on FB: Carrying a lighter mental load is key to our longevity and overall health. An excess of stress both intensifies and heightens the risk of many common health issues, such as heart disease, obesity, depression, gastrointestinal problems, asthma, and cognitive ...
by circular
Fri Oct 07, 2022 9:12 pm
Forum: Science and Research
Topic: A down side to omega 3 FAs in E4s?
Replies: 4
Views: 339

Re: A down side to omega 3 FAs in E4s?

I thought I'd try to find some sort of guidance as to what iron/ferritin levels might be safe for brain health. I remember a very old thread in these forums about it and I'll try to find that. FWIW, Circ, target range for ferritin on ReCODE Reports is 40-160. Thanks floramaria! Mine is only about 5...
by circular
Wed Oct 05, 2022 7:50 pm
Forum: Science and Research
Topic: A down side to omega 3 FAs in E4s?
Replies: 4
Views: 339

Re: A down side to omega 3 FAs in E4s?

A quick search got me to Differential effects of saturated and unsaturated free fatty acids on ferroptosis in rat β-cells : Abstract Elevated plasma concentrations of saturated free fatty acids (SFAs) are involved in pancreatic β-cell dysfunction and apoptosis, referred to as lipotoxicity. However,...
by circular
Wed Oct 05, 2022 3:03 pm
Forum: Science and Research
Topic: A down side to omega 3 FAs in E4s?
Replies: 4
Views: 339

A down side to omega 3 FAs in E4s?

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy (April 2022) Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical A...
by circular
Wed Sep 28, 2022 6:43 pm
Forum: Prevention and Treatment
Topic: Hormone replacement therapy - cyclical necessary?
Replies: 3
Views: 269

Re: Hormone replacement therapy - cyclical necessary?

I am on HRT and taking continuous estrogen... I'm still mystified why some give advice to cycle post-menopausal progesterone to better mimic pre-menopausal progesterone cycles, but we don't hear any corrollary advice to cycle post-menopausal estrogen to better mimic pre-menopausal estrogen. I think...