Thanks for the info on p-tau 181. Where can my doctor order p-tau 217? Do you have a link? Someone else may have better information, but from what I understand, the PrecivityAD2 test test is currently available now. You can learn more here. The downside is that p-tau 217 is not reported as a single...

I guess i should try to contact Dr mostert directly for info about the breseden protocol

I'd be happy to send an email of introduction to Dr. Mostert. Can you please PM me your email address?

Does anyone know the price for Labcorp's p-tau 181 test? I'm not sure about the p-tau 181 alone, but it's offered as a part of three test package called the Amyloid-Tau-Neurodegeneration (ATN) Profile as described here for $626. However, I would encourage you to wait for the p-tau 217 test which is...

The pathophysiological mechanisms by which the Tsimane seem to be protected against CAC development are unknown. Numerous potential explanations exist, and might relate to coronary artery disease risk factors, subsistence lifestyle, genetics, and inflammation or immune regulation. Tsimane have low ...

After I saw the video, I thought that minimising oxidised LDL should be the best kpi. Do you agree? I have to confess I haven't seen the video yet, but from what I've learned I think ApoB is far superior because for a smaller cost, you can assess all of your atherogenic particles- IDL, VLDL, Lp(a) ...

The discordance and hypothesized benefit is that lower ApoB with the same LDL-C would require lower LDL-P. And consequently with lower particles carrying the same cholesterol, the LDL particle size would be larger. As such, there would likely be less small dense LDL particles in the total populatio...

Thank you for weighing in, JNB! I've come to the same conclusion that you have that ApoB does reflect LDL-P vs. LDL-C. I like your graphics but do question why you would want the LDL pizza box empty. From my perspective, for the lowest risk, wouldn't we want it loaded with LDL-C?

Why? HDL similar, insulin almost the same, glucose slightly higher, but similar for all, triglycerides very similar. Why only LDL and ApoB differ (elevated in APOE4)? It's well known that E4 carriers hyperabsorb dietary fat. The leading theory is that as the ancestral (original) APOE allele carrier...

My guess is that the lower LDL-P would be reflected as each low density lipoprotein has an ApoB attached that has nothing to do with it's cargo — LDL-C. Does that seem to be correct?

I've recently become interested in ApoB as a vascular biomarker based upon Peter Attia's recommendations, but I'm trying to figure out if it accounts for discordancy between LDL-C and LDL-P per MESA data. nihms-274658-f0002-1.jpg From what I understand ApoB measures atherogenic chylomicrons, very lo...