Search found 5489 matches

by circular
Thu Mar 24, 2022 3:26 pm
Forum: Announcements and Events
Topic: Gauging Interest in a Trial with Valter Longo, PhD
Replies: 30
Views: 2735

Re: Gauging Interest in a Trial with Valter Longo, PhD

To Tincup's good suggestion that I read his book, unfortunately I'm a slow reader and don't have time to fit books in. If he comes out with an audiobook I can listen while getting other things done. The-Longevity-Diet-Audiobook,Audible Thanks Tincup! Sorry to have troubled you again. When I followe...
by circular
Thu Mar 24, 2022 2:22 pm
Forum: Announcements and Events
Topic: Gauging Interest in a Trial with Valter Longo, PhD
Replies: 30
Views: 2735

Re: Gauging Interest in a Trial with Valter Longo, PhD

His approach is based is on epidemiological evidence derived from Blue Zones. He sees no reason why this same approach wouldn't work for us. If this were to hold up, wouldn't we see E4 carriers represented among the centenarians in the Blue Zones? As you know, we don't. I like the idea of designing...
by circular
Thu Mar 24, 2022 2:06 pm
Forum: Announcements and Events
Topic: Discount for Prolon & Reset
Replies: 7
Views: 775

Re: Discount for Prolon & Reset

Our friends at L-Nutra have passed along a 20% discount to members of our community for their five day fasting mimicking diet product called Prolon and their one-day fasting product called Reset. Use 'ApoE' as your discount code (for both ProLon and Reset) at checkout. You can use the code at eithe...
by circular
Mon Mar 21, 2022 4:06 pm
Forum: Science and Research
Topic: Researchers study how gene expression changes in the brain in Alzheimer's disease
Replies: 2
Views: 211

Re: Researchers study how gene expression changes in the brain in Alzheimer's disease

The study is the most complete transcriptomic analysis of human astrocytes in Alzheimer's disease to date and is of great relevance due to the number of samples analyzed. The results highlight the need to use molecular data to stratify patients into more genetically homogeneous groups for clinical ...
by circular
Mon Mar 21, 2022 1:24 pm
Forum: Science and Research
Topic: Lithuanian researchers' algorithm that could detect Alzheimer’s disease gets closer to practical application
Replies: 5
Views: 305

Re: Lithuanian researchers' algorithm that could detect Alzheimer’s disease gets closer to practical application

Wow. MRIs seem like a potentially more expensive approach then blood biomarkers, but maybe this will end up being more sensitive and specific in the long run. A lot of neuron loss to the Hippocampus and you have AD. Neuron loss starts decades prior to symptoms. Some neuron loss with aging is consid...
by circular
Mon Mar 21, 2022 11:31 am
Forum: Announcements and Events
Topic: Gauging Interest in a Trial with Valter Longo, PhD
Replies: 30
Views: 2735

Re: Gauging Interest in a Trial with Valter Longo, PhD

Also, I’m curious to hear your thoughts about this approach. While I'm 3/4 and not eligible, I would be interested in better understanding Dr. Longo's specific research aim here. What endpoints does Dr. Longo plan to examine: chronological age, biological age, development of MCI/AD, brain imaging, ...
by circular
Sun Mar 20, 2022 11:23 am
Forum: Our Stories
Topic: Spreadsheet to Track Biomarker Targets and Ranges
Replies: 14
Views: 3782

Re: Spreadsheet to Track Biomarker Targets and Ranges

This spreadsheet is an absolutely phenomenal resource. Thanks for putting it together, @circular! Gee thanks! I'm afraid I haven't had a chance to focus on updating it much for over five years due to caregiving roles squeezing my time and cognitive bandwidth! It may be that some of the Bredesen mar...
by circular
Sat Mar 19, 2022 9:59 am
Forum: Prevention and Treatment
Topic: Prodrome blood test results, initial and over time
Replies: 49
Views: 4998

Re: Prodrome blood test results, initial and over time

Does anyone know if there have been studies showing how much blood plasmolagens fluctuate on average during, say, a twenty-four hour period, all other things being equal (ideally but not probably). Is there a certain time of day established to be the best time to test to catch their expected lowest...
by circular
Sat Mar 19, 2022 8:11 am
Forum: Prevention and Treatment
Topic: Prodrome blood test results, initial and over time
Replies: 49
Views: 4998

Re: Prodrome blood test results, initial and over time

I remain confused how NeuroRegain at 0.5 mg plasmalogens per capsule. appears to work and Goodenowe advocates a much larger dose daily, several hundredfold more. We are dealing with a large pharmaceutical company and the CEO and owner is frustrated with me when I cannot categorically specify a dail...
by circular
Wed Mar 16, 2022 8:05 pm
Forum: Science and Research
Topic: Lithuanian researchers' algorithm that could detect Alzheimer’s disease gets closer to practical application
Replies: 5
Views: 305

Re: Lithuanian researchers' algorithm that could detect Alzheimer’s disease gets closer to practical application

Work in progress is improving detecting the disease. Hopefully it gets widespread adoption. from the subtitle above "Lithuanian researchers from Kaunas University of Technology (KTU) improved an algorithm that detects Alzheimer’s disease from magnetic resonance imaging (MRI) images " http...