Here's a great blog (from Spunky) presenting the low-fat perspective. I pulled 3 of the studies outlined here re. Alzheimer's and already listed them in this category. I'm sure there's plenty of others to pull out... https://robustbiology.wordpress.com/2013/02/21/heart-disease-alzheimers-cancer-and-...

Here's a good common sense look at exercise. Cordain (et.al.) surmises that much of today's chronic illness is the result of an indoor sedentary life, Might help explain WHY E4s in developing countries don't go on to develop AD or CVD.(Unfortunately, E4s are not specifically addressed.) Organic Fitn...

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet http://ajpendo.physiology.org/content/304/4/E392 Abstract: The consumption of high-fat/calorie diets in modern societies is likely a major contributor to the obesity epidemic, which can increase the prevale...

Thanks for weighing in, Spunky. True, not all of these links are about ketogenic diets, but all indicate (in one way or another) that a diet higher in fat is either neuroprotective or cardioprotective. I'm in no way trying to draw conclusions or make dietary recommendations. I'm just trying to provi...

Serum cholesterol and cognitive performance in the Framingham Heart Study.http://www.ncbi.nlm.nih.gov/pubmed/15673620 CONCLUSIONS: Lower naturally occurring TC levels are associated with poorer performance on cognitive measures, which place high demands on abstract reasoning, attention/concentratio...

Potential benefits of adherence to the Mediterranean diet on cognitive health. http://www.ncbi.nlm.nih.gov/pubmed/23228285 "This dietary pattern is characterised by a high consumption of plant foods (i.e. vegetables, fruits, legumes and cereals), a high intake of olive oil as the main source o...

High total cholesterol levels in late life associated with a reduced risk of dementia
http://www.neurology.org/content/64/10/1689.abstract

Total cholesterol and risk of mortality in the oldest old
http://www.ncbi.nlm.nih.gov/pubmed/9343498

Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials.
http://www.ncbi.nlm.nih.gov/pubmed/20458092

CONCLUSIONS: Nut consumption improves blood lipid levels in a dose-related manner, particularly among subjects with higher LDL-C or with lower BMI.

Characterization of the lipid profile in dementia and depression in the elderly
http://www.ncbi.nlm.nih.gov/pubmed/17712096

"Low plasma levels of total cholesterol and HDL-C are associated with cognitive impairment and depressive symptomatalogy in elderly individuals."

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet http://www.nejm.org/doi/full/10.1056/NEJMoa1200303?viewType=Print&viewClass=Print&activeTab=comments&page=3 Conclusions: Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin ...