Search found 2019 matches

by NF52
Sat Apr 01, 2017 7:10 am
Forum: Science and Research
Topic: CAD106 and CNP520
Replies: 134
Views: 60770

Re: CAD106 and CNP520

Welcome, P45VA! I too am in the Georgetown site Generations Study, and want to welcome you warmly to the group of us who have enrolled in this study and are on this ApoE4.info site. When you say you haven't started in the "second phase" of testing yet, do you mean you haven't met with the ...
by NF52
Tue Mar 28, 2017 12:44 pm
Forum: Science and Research
Topic: CAD106 and CNP520
Replies: 134
Views: 60770

Re: CAD106 and CNP520

Hi Study Buddies! My April 3 date to start the fun has been pushed back. I was supposed to get the amyloid PET scan last Friday but heard two hours before that the supplier called and said they couldn't supply the Amyvid for the scan! The study coordinator and nurse were both VERY apologetic. Since ...
by NF52
Mon Mar 27, 2017 7:13 am
Forum: Announcements and Events
Topic: Generation Study
Replies: 4
Views: 2876

Re: Generation Study

JulieG, Thanks for bringing attention to the important Generations Study of two drugs designed to prevent or delay development of mild cognitive impairment and Alzheimer's in ApoE 4/4s. The description you linked to from the National Institute of Aging is very clear and accurate--with one recent cha...
by NF52
Sun Mar 19, 2017 8:13 pm
Forum: Science and Research
Topic: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?
Replies: 6
Views: 3132

Re: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?

Hi ScoutM, The regular study goes for 5 years, with the earliest people (of whom I think "lol" is one), starting in 2016 and finishing in 2021. I started in 2017, so will finish in 2022. All of us can choos to drop out at any time, and the study will also end if an outside data-monitoring ...
by NF52
Sun Mar 19, 2017 9:26 am
Forum: Science and Research
Topic: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?
Replies: 6
Views: 3132

Re: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?

And in January, Alzheon announced that Nobel Laureate Dr. Stanley Prusiner, of UCSF, has been appointed as chair of their Scientific Advisory Board. That sounds like a company that thinks it has a blockbuster drug in ALZ-801. No mention of any trials with pre-clinical populations, however. http://ww...
by NF52
Sun Mar 19, 2017 9:17 am
Forum: Science and Research
Topic: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?
Replies: 6
Views: 3132

Re: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?

Just found this from a 2015 article on the fine-tuning of the earlier version of "tramiprosate—a chemically modified form of the amino acid taurine naturally found in seaweed". Taurine comes up a fair amount as a supplement people have found helpful--maybe now some clinical evidence for th...
by NF52
Sat Mar 18, 2017 3:05 pm
Forum: Science and Research
Topic: 13th Int'l Conf. on AZ and Park.- new hope for 4/4s?
Replies: 6
Views: 3132

13th Int'l Conf. on AZ and Park.- new hope for 4/4s?

Just came across a reference to an Alzion drug being featured in 2 oral presentations and 2 poster sessions at a conference coming up March 29-April 2 in Vienna. http://adpd2017.kenes.com Alzion is reporting "sustained cognitive and functional improvement above baseline in Mild patients" i...
by NF52
Thu Mar 16, 2017 11:08 am
Forum: Science and Research
Topic: CAD106 and CNP520
Replies: 134
Views: 60770

Re: CAD106 and CNP520

FYI, my Generations Study buddies: I was curious about the reports from both of you on increased blood pressure, so used the magic of Google. Found this 2016 study that showed 10% of people in a Phase I study of CAD106 showed a non-serious adverse event of "hypertension". Don't know about ...
by NF52
Thu Mar 16, 2017 10:44 am
Forum: Science and Research
Topic: EARLY clinical trial opportunity
Replies: 4
Views: 2303

Re: EARLY clinical trial opportunity

Hi Haslk! As someone who is in the Generations Study for 4/4's, I'm all in favor of making people aware of other studies, An advantage of the EARLY study is that it includes both 3/4 and 4/4 participants, using the BACE inhibitor approach. Here's the Clinical Trials.gov link for more description. ht...
by NF52
Sat Mar 11, 2017 9:50 pm
Forum: Science and Research
Topic: Can my son have 2x APOE-E4 allele when I have one & my wife has none?
Replies: 5
Views: 2479

Re: Can my son have 2x APOE-E4 allele when I have one & my wife has none?

Hi APOE4 dad! Glad you found this helpful site. I'm guessing your son is concerned about the 4/4 status more than how he got it. Sounds like maybe your wife's report was ambiguous? I hope you reassure your son that APOE 4/4 is a risk factor for late-onset Alzheimer's disease (acronym LOAD), meaning ...