Search found 2152 matches

by NF52
Mon Nov 18, 2024 8:03 pm
Forum: Prevention and Treatment
Topic: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)
Replies: 171
Views: 362873

Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

This seems like the right place to post an article from the Nov. 14 issue of Alzforum on a panel discussion of the AHEAD3-45 Clinical Trials. As the article notes: Lecanemab was approved for people with mild cognitive impairment or mild dementia due to Alzheimer’s, but trial data show it works bett...
by NF52
Mon Nov 18, 2024 7:35 pm
Forum: Prevention and Treatment
Topic: "Leqembi: Side Effects No Worse in Clinical Use Than They Were in Trial"
Replies: 0
Views: 426

"Leqembi: Side Effects No Worse in Clinical Use Than They Were in Trial"

Alzforum posted a summary of several presentations by clinicians in the U.S, UK, and Japan on numbers and safety data for Leqembi (lecanemab) at the recent CTAD (Clinical Trials on Alzheimer's Disease) conference. Details are available here: Leqembi: Side Effects No Worse in Clinical Use Than They W...
by NF52
Mon Nov 18, 2024 4:40 pm
Forum: Getting Started
Topic: Hello, i did a MyHeritage test!
Replies: 12
Views: 8797

Re: Hello, i did a MyHeritage test!

... Regarding Promethease, I did subscribe and regarding ApoE section what they tell: - rs7412(C;C) part of APOE4 genoset evaluation -> this one I knew, quite standard and usual. - rs440446(C;G) increased risk in men for biliary conditions -> I'll disregard this one as a female & not related to...
by NF52
Sat Nov 16, 2024 12:41 pm
Forum: Prevention and Treatment
Topic: FDA approves "Kisunla" (donanemab) for MCI/Mild AD
Replies: 14
Views: 2045

Re: FDA approves "Kisunla" (donanemab) for MCI/Mild AD

ARIA 3.PNG ARIA 2.PNG ARIA 1.PNG https://assets.ctfassets.net/mpejy6umgthp/4vbew8MSRVpgzDkYrcQzSU/45e7cd8dc17cb50b581582a5b2966f46/DV-021572_24wTB6-MDD.pdf Thank you for posting the slide presentation from the recent CTAD conference presentation on a trial using 4 different titration methods for do...
by NF52
Fri Nov 15, 2024 11:11 am
Forum: Prevention and Treatment
Topic: FDA approves "Kisunla" (donanemab) for MCI/Mild AD
Replies: 14
Views: 2045

Re: FDA approves "Kisunla" (donanemab) for MCI/Mild AD

Do we know if titrating the drug will diminish the length of efficacy? Right now the slowing delay is pretty minimal. According to this from the University of San Francisco, https://memory.ucsf.edu/lecanemab#:~:text=In%20a%20large%20clinical%20study,18%20months%20of%20consistent%20treatment. In a l...
by NF52
Fri Nov 15, 2024 6:56 am
Forum: Our Stories
Topic: New E4/E4 Needing Encouragement
Replies: 19
Views: 14878

Re: New E4/E4 Needing Encouragement

I am still in the shock/anger/terror stage, but I hope that I will settle into some new kind of normal soon. I am exhausted from trying to gain information about this, and I have been disappointed with the lack of support/direction I have received from the providers I have consulted so far. I feel ...
by NF52
Fri Nov 15, 2024 5:52 am
Forum: Prevention and Treatment
Topic: Is mild sedation ok?
Replies: 2
Views: 309

Re: Is mild sedation ok?

Hi, I have some heart history, and had bypass surgery about 18 months ago. While doing it, they inserted a "clip," which is supposed to prevent (or reduce the risk of) blood clots caused by A-fib. And I'm on Eliquis, blood thinner. This morning, the cardiologist suggested to me that, give...
by NF52
Thu Nov 14, 2024 8:26 pm
Forum: Prevention and Treatment
Topic: FDA approves "Kisunla" (donanemab) for MCI/Mild AD
Replies: 14
Views: 2045

Re: FDA approves "Kisunla" (donanemab) for MCI/Mild AD

I somehow managed to get through 3 master’s degrees without a statistics course. Yet I think you and TheresaB may have some common ground. It seems to me that the biggest question is whether the titration schedule, which is plausible, will hold up with bigger numbers of 4/4s . I hope clinical practi...
by NF52
Thu Nov 14, 2024 4:41 pm
Forum: Prevention and Treatment
Topic: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)
Replies: 171
Views: 362873

Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Sorry if this isn't the best thread for this question. I have a relative who recently was started on Lecanemab. The first infusion went okay, but a couple days later his urinary tract closed up and he had to be catheterized to get relief. The same thing happened on his second infusion and so they h...
by NF52
Mon Nov 11, 2024 5:51 pm
Forum: Prevention and Treatment
Topic: FDA approves "Kisunla" (donanemab) for MCI/Mild AD
Replies: 14
Views: 2045

Re: FDA approves "Kisunla" (donanemab) for MCI/Mild AD

Big News! By slightly changing the titration schedule for Donanemab, ARIA risk fell by 67% for e44s . That is truly astonishing! With this change, e44s would have a lower ARIA risk than that previously reported for the e34s. The e34s saw a ~40% decrease in their ARIA risk, while the e33s saw a 20% ...