Search found 1141 matches

by TheresaB
Sat Feb 03, 2024 9:51 am
Forum: Announcements and Events
Topic: Intro to APOE4
Replies: 0
Views: 13006

Intro to APOE4

If you haven’t read the APOE4.info wiki Introduction to APOE4 lately, now might be a good time to revisit. It has had quite a number of updates the past few weeks. There have been some really interesting papers published recently. Adding them led to other updates, sprucing up, and additional graphics.
by TheresaB
Fri Feb 02, 2024 3:33 pm
Forum: Our Stories
Topic: Blue Light Blocking Glasses
Replies: 3
Views: 13564

Re: Blue Light Blocking Glasses

I don't personally have a recommendation, but maybe this article might offer a good option for you.

Best Blue-Light-Blocking Glasses of 2024
by TheresaB
Thu Feb 01, 2024 5:54 am
Forum: Science and Research
Topic: Approval of Aduhelm (aducanumab), what went wrong
Replies: 5
Views: 14989

Re: Approval of Aduhelm (aducanumab), what went wrong

A short recap on the controversial history of Aducanemab/Aduhelm. Aducanemab/Aduhelm was the first of the two -mab (monoclonal antibody) drugs approved by the FDA (Lecanemab/Leqembi was the 2nd, the final determination on Donanemab is currently under consideration. Gantenerumab, Solanezumab and Cren...
by TheresaB
Wed Jan 31, 2024 7:14 pm
Forum: Science and Research
Topic: Approval of Aduhelm (aducanumab), what went wrong
Replies: 5
Views: 14989

Re: Approval of Aduhelm (aducanumab), what went wrong

Just announced (1/31/2024) in this article: Biogen to cease production of controversial Alzheimer’s drug Drugmaker Biogen will discontinue development and marketing for Aduhelm, a landmark Alzheimer’s disease treatment that also provoked controversy over conflicting data around its efficacy, the com...
by TheresaB
Wed Jan 31, 2024 7:13 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 387935

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Just announced (1/31/2024) in this article: Biogen to cease production of controversial Alzheimer’s drug Drugmaker Biogen will discontinue development and marketing for Aduhelm, a landmark Alzheimer’s disease treatment that also provoked controversy over conflicting data around its efficacy, the com...
by TheresaB
Wed Jan 24, 2024 3:59 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 387935

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

I respectfully have a different view: that J11--and I for that matter--are not celebrating drugs; we are celebrating progress in identifying SOME--but not all--drivers of Alzheimer's pathology, specifically amyloid and tau, which seem more prevalent and more toxic in ApoE 4 carriers an earlier age,...
by TheresaB
Wed Jan 24, 2024 6:20 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 387935

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Your response precisely highlights my concern with you and your posts. Not once did you mention ApoE4. Despite belonging to this site for 10 years, you have refused to follow the decorum of these threads by such things as “not being bothered” to learn how to quote others. These forums are dedicated ...
by TheresaB
Tue Jan 23, 2024 8:24 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 387935

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

If you're not here for another celebration, you're in the wrong place! No, you’re in the wrong place. Your celebratory threads misrepresent reality and completely disregard the purpose of these forums as being dedicated to understanding the APOE-ε4 allele and how it affects health. You have co-opte...
by TheresaB
Mon Jan 22, 2024 8:05 am
Forum: Science and Research
Topic: Approval of Aduhelm (aducanumab), what went wrong
Replies: 5
Views: 14989

Re: Approval of Aduhelm (aducanumab), what went wrong

ApoE4s are at greater risk for brain arterial disorders (for more info refer to the ApoE4.info wiki article ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s ) I’ve written here in these forums before that this susceptibility poses a greater risk for us ApoE4s with these -...
by TheresaB
Mon Jan 22, 2024 8:02 am
Forum: Prevention and Treatment
Topic: Donanemab and Lecanemab
Replies: 53
Views: 260198

Re: Donanemab and Lecanemab

ApoE4s are at greater risk for brain arterial disorders (for more info refer to the ApoE4.info wiki article ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s ) I’ve written here before repeatedly that this susceptibility poses a greater risk for us ApoE4s with these -mab d...