Search found 2551 matches

by SusanJ
Mon Nov 13, 2023 4:37 pm
Forum: Our Stories
Topic: APOE 4/4 - Dizziness that won't go away
Replies: 12
Views: 10271

Re: APOE 4/4 - Dizziness that won't go away

Have any other APOE's had a similar experience with dizziness or any theories I could research? I was diagnosed with Meniere's many years ago after a similar round at the doctors. And I could never really link my vertigo to anything. It just came and went, but when it came, it would be wicked and s...
by SusanJ
Tue Oct 31, 2023 2:59 pm
Forum: Science and Research
Topic: Allopregnanolone has the potential to delay neurodegeneration in early Alzheimer's
Replies: 1
Views: 2936

Allopregnanolone has the potential to delay neurodegeneration in early Alzheimer's

Early in the clinical research cycle, but in this phase, 62% of the participants were ε4 carriers. Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early ...
by SusanJ
Mon Oct 30, 2023 5:50 pm
Forum: Prevention and Treatment
Topic: Has anyone else gotten the new Abeta 42/40 test?
Replies: 16
Views: 8502

Re: Has anyone else gotten the new Abeta 42/40 test?

My father took the Quest test, and it said his result was "intermediate." He then went through the initial testing for the AHEAD trial, and they said his blood amyloid levels were low, and he didn't qualify for the trial — solidifying my belief that the Quest test is giving people scary r...
by SusanJ
Mon Oct 30, 2023 5:38 pm
Forum: Our Stories
Topic: Did you tell your family?
Replies: 7
Views: 4792

Re: Did you tell your family?

I'm sure some of you have had to deal with these issues, so I'm curious how you thought about it! I think you need to respect your mom's desire not to know, and therefore you don't share your status to your half-siblings. Once that info is out there, it could to easily get back to her. However, has...
by SusanJ
Mon Oct 09, 2023 9:32 am
Forum: Science and Research
Topic: AD and higher blood levels of BCAAs
Replies: 0
Views: 2324

AD and higher blood levels of BCAAs

Interesting that they used the association of BCAAs between T2D and AD and found that lowering BCAAs made a difference in AD progression in their mouse model. Shin learned about the benefits of the compound, BT2, through his research into the brain and neurodegenerative disorders during the past 10 ...
by SusanJ
Tue Aug 15, 2023 9:15 am
Forum: Our Stories
Topic: Jim's Journey
Replies: 12
Views: 5930

Re: Jim's Journey

Increasing calories (and anaerobic exercise) makes sense, through doing so with carbs (admittedly consistent with these recommendations) would require a shift in perspective (vs. just eating more of my current diet) and potentially raise concern about oxidized LDL (advanced glycation end products; ...
by SusanJ
Thu Aug 10, 2023 9:31 am
Forum: Our Stories
Topic: Jim's Journey
Replies: 12
Views: 5930

Re: Jim's Journey

Physical Challenges: Feel very fit but underweight Cardio excellent but muscle mass lacking aerobic - 90% anaerobic - 10% Appetite Challenges: Hungry most afternoons, even after meals. Caloric deficit? Nutritionally deficient? I do a similar diet, the final piece going low oxalate almost 3 years ag...
by SusanJ
Wed Jul 26, 2023 5:50 pm
Forum: Prevention and Treatment
Topic: High energy expenditure and APOE 4
Replies: 22
Views: 4773

Re: High energy expenditure and APOE 4

I'm going to switch to a 12 hour eating window to fit in more meals and fatten up. I won't be able to exercise very much on my trip so hopefully that will also provide an opportunity to gain weight. I'm traveling with 3 pounds of nuts, cans of mackeral, and packets of olive oil. From a fellow, stru...
by SusanJ
Sat Jul 15, 2023 9:08 pm
Forum: Prevention and Treatment
Topic: Gene IL-6 and AD risk
Replies: 4
Views: 637

Re: Gene IL-6 and AD risk

This seems like a sensible approach to me (?) Homocysteine is an easy test, so probably worth doing before you throw TMG (betaine) in the mix. Some people can control high homocysteine just with folate, B12, and B6 supplementation. If you want to do a deeper dive into all things related to folate, ...
by SusanJ
Tue Jul 11, 2023 9:46 pm
Forum: Prevention and Treatment
Topic: Gene IL-6 and AD risk
Replies: 4
Views: 637

Re: Gene IL-6 and AD risk

Has anybody looked at this, its a big enough challenge having APOE4 status let alone having another AD risk! Our genes are not necessarily our destiny, but there are things we can do to support/counter variants we'd rather not have. In relation to IL6-174 Gene and AD risk, this article seems to be ...