Search found 300 matches

by BrianR
Sat May 13, 2023 7:31 am
Forum: Science and Research
Topic: Very Good Peter Attia podcast
Replies: 16
Views: 11918

Re: Very Good Peter Attia podcast

But, I can say that my dad (who is 83 and is significantly starting to decline cognitively) lost his sense of smell and taste over 10 years ago. I had no idea that there was a possible connection. My father lost much of his sense of smell and taste in his early fifties. Now 90, he definitely has co...
by BrianR
Sun Apr 02, 2023 10:56 am
Forum: Science and Research
Topic: Review: APOE and immunity: Research highlights
Replies: 0
Views: 1488

Review: APOE and immunity: Research highlights

Open access. Review article inspired by the October 2021 Alzheimer's Association's APOE and Immunity virtual conference. https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13020 APOE and immunity: Research highlights Courtney M. Kloske, et al. Alzheimer’s & Dementia First publishe...
by BrianR
Sat Mar 18, 2023 10:03 am
Forum: Science and Research
Topic: CETP: Corporate speculation re: blocking AD and more
Replies: 1
Views: 1494

Re: CETP: Corporate speculation re: blocking AD and more

For those who are very interested in lipids. From Thomas Dayspring " Illustration of INDIRECT Reverse Cholesterol Transport where HDL acquires cellular cholesterol, esterifies it to cholesteryl ester & then using CETP, transfers CE to LDL which delivers the CE to the liver: returning CE to ...
by BrianR
Sat Mar 18, 2023 9:54 am
Forum: Science and Research
Topic: CETP: Corporate speculation re: blocking AD and more
Replies: 1
Views: 1494

CETP: Corporate speculation re: blocking AD and more

Rather than cluttering up @alantisw's post, I'll add this related information separately. Thomas Dayspring recommended this bit of research description from New Amsterdam Pharmaceuticals which provides an overview of their CETP inhibitor Obicetrapib. To save you a trip to their fancy web site, here ...
by BrianR
Sat Mar 11, 2023 7:41 am
Forum: Science and Research
Topic: Fructose leads to Alzheimer’s? (new hypothesis and wiki)
Replies: 6
Views: 3731

Re: Fructose leads to Alzheimer’s? (new hypothesis and wiki)

Fascinated by this, I felt we needed a new ApoE4.info wiki on this subject, it can be found here: From Fructose to Alzheimer's . I tried to keep the discussion high level and accessible, but there's so much to this subject, I hope I did it justice. ... Theresa, this is a superb addition to the wiki...
by BrianR
Sat Feb 18, 2023 8:33 am
Forum: Science and Research
Topic: Combined metabolic activators improve cognitive functions in AD patients
Replies: 2
Views: 2221

Re: Combined metabolic activators improve cognitive functions in AD patients

Interesting - thanks Plumster. I wonder if they have the resources to proceed to a meaningful phase 3 trial in Turkey or somewhere else in the EU? (Maybe even including ApoE genotyping this time.) It's difficult for me to believe that anyone would fund a large phase 3 trial in the US for a relativel...
by BrianR
Tue Dec 27, 2022 9:28 am
Forum: Science and Research
Topic: Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia
Replies: 0
Views: 706

Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia

Open access. Three year study with moderate sized population. https://www.frontiersin.org/articles/10.3389/fnagi.2022.927656/pdf Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia Tung Hsin, Lin Ching-Heng, Chen Yi-Ming, Lee Wei-Ju, Chien Li...
by BrianR
Fri Dec 23, 2022 5:13 pm
Forum: Our Stories
Topic: Using statins with APOE 3/4 genetics
Replies: 8
Views: 2142

Re: Using statins with APOE 3/4 genetics

... but I’ve read that statins shouldn’t be taken if you have a APOE4 marker. For what it's worth, Peter Attia uses blood plasma levels of desmosterol as an indicator of whether statins might be adversely affecting brain lipid levels in his patients: From a clinical perspective, low desmosterol lev...
by BrianR
Fri Dec 16, 2022 12:54 pm
Forum: Science and Research
Topic: Anti-amyloid antibody drugs and brain shrinkage
Replies: 3
Views: 1067

Re: Anti-amyloid antibody drugs and brain shrinkage

I quoted one of those articles noting brain shrinkage in the Lecanamab: Efficacy, Side Effects, and More thread. This is concerning given that brain shrinkage is associated with dementia and we don't know long term effects of these drugs yet. Thanks Theresa, I had forgotten that. Excellent question...
by BrianR
Sun Dec 11, 2022 8:26 am
Forum: Science and Research
Topic: Anti-amyloid antibody drugs and brain shrinkage
Replies: 3
Views: 1067

Anti-amyloid antibody drugs and brain shrinkage

Two very readable opinion pieces touching on evidence that anti-amyloid antibody treatments may exacerbate brain shrinkage. The summary is that this apparent phenomenon ought to be better understood before widespread use of these drugs (e.g. lecanemab). Derek Lowe blog (motivated by the Stat article...