Does anyone have information or experience with a phenomenon that might be called pseudo-diabetes or starvation diabetes, where one’s insulin resistance appears to increase dramatically on a ketogenic diet? I am not familiar with those terms, but I have heard of Physiological Insulin Resistance aka...

Hi all, My loved one and I just went to her neurologist, and he said that lecanemab is available now and donanemab will likely be available by the end of this year/early 2024. Lecanemab requires either a amyloid PET scan or spinal fluid for biomarkers. Donanemab requires consistent imaging, and rig...

So, is soy beneficial, acceptable, or should be avoided in 4/4? IIRC, the original version of the Bredesen protocol, IIRC, says to avoid soy. But the 2020 book (that I own) most certainly sees soy as acceptable. This is one of my major confusions regarding my diet--so what's your take on it? I am n...

But based on my overall health, and the fact that every few weeks my generally dismal HRV increases by 500%, makes me wonder if something else is going on. HRV is controlled by the vagus nerve. Sounds as if recent life events have impacted your vagal tone. You can read more in our ApoE4.info wiki p...

It sounds promising to me but I wanted to ask the more experienced folks on this forum for their thoughts. I agree that this does sound promising. But then there are a whole lot of mice studies that sound promising, they don't always translate to humans. From this graphic showing the hierarchy of s...

I found this supplement on Organfi. Here's a link: https://www.organifishop.com/products/f ... s=e&_v=1.0 From the back label, Supplement Facts Serving Size: 2 Capsules Servings Per Container: 30 Amount Per Serving Organic Lion's Mane (Hericlum erinaceus) (Fruiting Body) Extract 1,000mg Neurofa...

I have landed on a common sense approach. Know your body. Pay attention to it. One caution about this approach. Years ago I thought I was eating well and felt great. Then I had biomarkers taken and my inflammatory markers were high. Like you said, know your body, this shouldn't have surprised me as...

Thanks for posting this very interesting talk, science based with actionable tips. Very appreciated. I'd like to hear more from her. I agree with you that this is a very interesting talk. You said you'd like to hear more from her. Just in case you didn't see my comment above, Dr Peter Attia conduct...

I think this was discussed in the Hormone Replacement Therapy E4 Women thread. I know it was discussed on our ApoE4.info facebook page, including these comments: I’d be very hesitant to draw any conclusions from this observational study as synthetic hormones were used vs. the bioidentical hormones w...

Hi, I'm Dustin, 3/4. It seems that I need cervical disk replacement surgery (C6/C7, I think it was). I recalled that there are concerns about GA and long-term AD risk, so I've tried to research this a bit with PubMed and the web in general, but don't have a very good sense of the current best pract...