Yes, Plumster, I'll definitely post here. I am hoping my "maintenance dose" will be less than what I am taking now!Plumster wrote:Thanks, Floramaria. Dr. Goodenowe referred to a "maintenance dose" in an interview a while back and he seemed uncertain what it would be. Just wondering if he or anyone else has a good idea of what that might be. Knowing your results would be helpful too.
PeterM wrote:Thanks, Floramaria, please do keep us posted! I’m sure more than a few of us are following your plasmalogen journey with interest. Personally I’m still on the fence about testing first. My plan as of now is to use both the neuro form and glia form, but on alternate days, then test in 6 months to see where my levels are. Unless one has a stellar TG/HDL ratio at baseline, waiting to test might financially be a more prudent way to begin. In any case, I appreciate you keeping us up-to-date.
Plasmalogens are a subclass of cell membrane glycerophospholipids that typically include vinyl- ether bond at the sn-1 position and polyunsaturated fatty acid at the sn-2 position. They are highly abundant in the neuronal, immune, and cardiovascular cell membranes. Despite the abundance of plasmalogens in a plethora of cells, tissues, and organs, the role of plasmalogens remains unclear. Plasmalogens are required for the proper function of integral membrane proteins, lipid rafts, cell signaling, and differentiation. More importantly, plasmalogens play a crucial role in the cell as an endogenous antioxidant that protects the cell membrane components such as phospholipids, unsaturated fatty acids, and lipoproteins from oxidative stress. The incorporation of vinyl-ether linked with alkyl chains in phospholipids alter the physicochemical properties (e.g., the hydrophilicity of the headgroup), packing density, and conformational order of the phospholipids within the biomembranes. Thus, plasmalogens play a significant role in determining the physical and chemical properties of the biomembrane such as its fluidity, thickness, and lateral pressure of the biomembrane. Insights on the important structural and functional properties of plasmalogens may help us to understand the molecular mechanism of membrane transformation, vesicle formation, and vesicular fusion, especially at the synaptic vesicles where plasmalogens are rich and essential for neuronal function. Although many aspects of plasmalogen phospholipid involvement in membrane transformation identified through in vitro experiments and membrane mimic systems, remain to be confirmed in vivo, the compiled data show many intriguing properties of vinyl-ether bonded lipids that may play a significant role in the structural and morphological changes of the biomembranes. In this review, we present the current limited knowledge of the emerging potential role of plasmalogens as a modulator of the biomembrane morphology.
In conclusion, with the potential role of plasmalogens in biomembranes as a modulator of cell membrane physicochemical properties and morphology, plasmalogens cannot be regarded to function only as an internal antioxidant that maintains membrane lipids and proteins integrity. Plasmalogens affect both across the lipid bilayer (lipid asymmetry) and lateral dimension (lipid domains) and facilitate the formation of non-lamellar structures in the cell. Inducing membrane curvature initiates and promotes membrane fusion/fission, vesicular formation, and molecular transportation which are crucial for normal cell function (especially neuronal cells) and adaptation to stress conditions. This new aspect of plasmalogens in the bilayer membrane architecture has been tested in artificial membrane lipid systems and yet to be explored in vivo. Furthermore, in-depth study of the underlying molecular mechanism of inducing and selecting a specific spatial arrangement of bilayer-based membranes is indeed critical to the understanding of the association between cell membrane alteration and adjustment of cellular function and adaptation to stress and pathological conditions.
Plumster wrote:Thanks, Floramaria. Dr. Goodenowe referred to a "maintenance dose" in an interview a while back and he seemed uncertain what it would be. Just wondering if he or anyone else has a good idea of what that might be. Knowing your results would be helpful too.
ThankS for the book link, Tincup. Looks interesting. As a side note here in our plasmalogen thread: when I got the Quicksilver Metals Panel a couple of months ago, almost all of my nutrient metal levels were low even though I eat a mineral-rich diet and supplement too. In the post-test consult, I was told the same thing as you were told. Most likely I have absorption problems from low stomach acid. Recommendations were for HCl and digestive enzymes.Tincup wrote: The consultant suggested adding HCl and enzymes supplements when I eat. I did and my glucose control eating carbs got much better. Just after this suggestion, this book, "Why Stomach Acid Is Good for You: Natural Relief from Heartburn, Indigestion, Reflux and GERD" came through my feed. Reading it indicates that low stomach acid is very common as we age and may be a huge cause of poor digestion and not absorbing nutrients, like the iron and maybe the Cu..
johnseed wrote: I wonder what other tests there might be that would focus on this particularly so that I could get the best indication possible as to whether the supplements were having much effect there?
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