Phospholipid Therapy Review

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
circular
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Re: Phospholipid Therapy Review

Post by circular »

Quantifier wrote:... do you know of testing companies that test for TMAO?
If you're in the US, Quest Diagnostics provides it. It's availability through them, however, appears to vary by region.
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Quantifier
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Re: Phospholipid Therapy Review

Post by Quantifier »

[quote="circular"][/quote]

Wow, thanks! I'll see how this works.
nicolewilbanks
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Re: Phospholipid Therapy Review

Post by nicolewilbanks »

Julie G wrote: Mon Sep 20, 2021 8:01 am
However, despite the widespread use of PLT over the last 50 years, data on the benefits in healthy individuals is extremely limited.

On the other hand, the major long-term risks, though largely still hypothetical, are serious. Recent publications on high dietary intake of phosphatidylcholine and its correlation with increased all-cause mortality, increased risk of lethal prostate cancer and increased risk of acute myocardial infarction warrant serious reflection on the safety of long-term supplementation with phosphatidylcholine-containing products. A possible explanatory mechanism for the damage caused by the consumption of high levels of choline-containing products has already been shown in a clinical study.

Based on the analysis of all currently available data, we find that short-term supplementation with phosphatidylcholine is a potential treatment option for cases of known liver disease, cognitive impairment, or in conjunction with NSAIDs.

Whether the benefits may also outweigh the risks in a generally healthy population is unknown. If one decides to supplement with phospholipids, risk mitigation measures such as measurement of TMAO and stool analysis should be performed regularly.

We recommend against the use of phosphatidylcholine supplementation in the case of known CVD until the situation regarding the PC-related production of TMAO and its role in CVD has been further clarified.
Hi Ron! Thanks for sharing. This is decent info, but I'm not a fan of the lack of transparency with regard to whom it's coming from. I was able to track the team down, but wish they'd be more forthcoming with their identities, especially when sharing medical advice.

We've essentially concluded that the potential warnings surrounding choline supplementation should be heeded in the context of an overall unhealthy diet/lifestyle. That said, this is a perfect place to practice personalized, precision. For instance, I've recently learned through the Prodrome Blood Scan that I have lower levels of peripheral phosphatidylcholine despite my dietary intake and supplementation with CDP Citicoline. Today was my first day of 2 tsp of sunflower lectin dissolved in water and I plan to work up to a full TBS. All of my vascular risk factors are extraordinarily low, but perhaps I should check TMAO levels as I progress to be uber-cautious?
Julie,
Have you been able to work up to a full tabelspoon of lechtin as a replacement for citicoline?
Plumster
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Re: Phospholipid Therapy Review

Post by Plumster »

Quantifier wrote: Mon Oct 11, 2021 9:53 am
Julie G wrote:We've essentially concluded that the potential warnings surrounding choline supplementation should be heeded in the context of an overall unhealthy diet/lifestyle. That said, this is a perfect place to practice personalized, precision. For instance, I've recently learned through the Prodrome Blood Scan that I have lower levels of peripheral phosphatidylcholine despite my dietary intake and supplementation with CDP Citicoline. Today was my first day of 2 tsp of sunflower lectin dissolved in water and I plan to work up to a full TBS. All of my vascular risk factors are extraordinarily low, but perhaps I should check TMAO levels as I progress to be uber-cautious?
Hi Julie G, do you know of testing companies that test for TMAO?
Cleveland Heart Lab does.
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR
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