However, despite the widespread use of PLT over the last 50 years, data on the benefits in healthy individuals is extremely limited.
On the other hand, the major long-term risks, though largely still hypothetical, are serious. Recent publications on high dietary intake of phosphatidylcholine and its correlation with increased all-cause mortality, increased risk of lethal prostate cancer and increased risk of acute myocardial infarction warrant serious reflection on the safety of long-term supplementation with phosphatidylcholine-containing products. A possible explanatory mechanism for the damage caused by the consumption of high levels of choline-containing products has already been shown in a clinical study.
Based on the analysis of all currently available data, we find that short-term supplementation with phosphatidylcholine is a potential treatment option for cases of known liver disease, cognitive impairment, or in conjunction with NSAIDs.
Whether the benefits may also outweigh the risks in a generally healthy population is unknown. If one decides to supplement with phospholipids, risk mitigation measures such as measurement of TMAO and stool analysis should be performed regularly.
We recommend against the use of phosphatidylcholine supplementation in the case of known CVD until the situation regarding the PC-related production of TMAO and its role in CVD has been further clarified.
TMAO Some studies have suggested that eating red meat raises TMAO, which in turn increases the risk for heart disease, cancer, and all-cause mortality. However, the epidemiological evidence is inconsistent and virtually disappears when kidney disease and insulin resistance are considered as contributing factors. Additionally, none of these studies takes into account the health of the microbiome (where TMAO originates) and may underestimate the healthy user bias—the concept that those who eschew red meat may have overall healthier habits. We suspect that the small amount of unprocessed clean animal protein we recommend in the context of a heavily plant-based diet and healthy lifestyle will minimize the potential negative effect of TMAO.
Prostrate Cancer An inconsistent correlation has been found between egg consumption (choline intake) and prostate cancer that holds true only for North America. In countries where there is high egg consumption and plentiful vegetable intake, this correlation disappears. Newer research suggests that the unhealthy user bias traditionally associated with egg intake may be mediating this risk. We suspect that men who are otherwise following our heavily plant-based. no-sugar guidelines will minimize the potential risk. Men at higher risk due to progressive benign prostate enlargement or who are diagnosed with prostate cancer should be careful to meet but not exceed their choline needs.
Julie G wrote:I've recently learned through the Prodrome Blood Scan that I have lower levels of peripheral phosphatidylcholine despite my dietary intake and supplementation with CDP Citicoline.
But one question I always have with any kind of biomarker testing is just how frequently the thing being tested fluctuates. How telling is one test of peripheral phosphatidylcholine? Peripheral levels may be quite constant, and along with all the other variables relating to methodology and the like being sound, the test may be highly accurate. I just hope that this has been studied in depth.
NewRon wrote:ConsumerLab have just updated their choline review;
https://www.consumerlab.com/reviews/cho ... w/choline/
Julie G wrote:We've essentially concluded that the potential warnings surrounding choline supplementation should be heeded in the context of an overall unhealthy diet/lifestyle. That said, this is a perfect place to practice personalized, precision. For instance, I've recently learned through the Prodrome Blood Scan that I have lower levels of peripheral phosphatidylcholine despite my dietary intake and supplementation with CDP Citicoline. Today was my first day of 2 tsp of sunflower lectin dissolved in water and I plan to work up to a full TBS. All of my vascular risk factors are extraordinarily low, but perhaps I should check TMAO levels as I progress to be uber-cautious?
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