Genetic Risk Factor Links Alzheimer's Disease and Severe COVID-19

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TLS
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Genetic Risk Factor Links Alzheimer's Disease and Severe COVID-19

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An article published in Brain is interesting. A new gene for further research and study.

Highlight from the article:
The new study builds on previous work by the UCL team that reported a link between oligoadenylate synthetase 1 (OAS1) and Alzheimer's disease. The OAS1 gene is expressed in microglia, an immune cell that accounts for ~10–15% of the cells found in the brain. While the hallmark of Alzheimer's disease pathology is a build-up of amyloid plaques and TAU tangles in the brain, a growing body of research is demonstrating how the immune system – and in particular, inflammation – contributes.

In a genome wide association study (GWAS) of 2,547 people – 50% of which had Alzheimer's disease – Salih and colleagues identified a variant of the OAS1 gene, known as rs1131454, that was linked to an increased likelihood of having the disease.

Links Here:
Brain study: https://academic.oup.com/brain/advance- ... #304716203
Summary here: https://www.technologynetworks.com/geno ... -19-354528
UCL Gene Study, New approach identifies novel risk genes connected to microglia response in Alzheimer’s disease: https://www.ucl.ac.uk/ion/news/2019/oct ... alzheimers
apoe 3/4
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