gingipain inhibitor study fails

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rws
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gingipain inhibitor study fails

Post by rws »

In the infection hypothesis realm the failure of this trial looks like a blow to the P.gingivalis crowd. See

https://www.science.org/content/blog-po ... ng-s-great

Still enough other culprits existing, though.

Regards,
NF52
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Re: gingipain inhibitor study fails

Post by NF52 »

rws wrote:In the infection hypothesis realm the failure of this trial looks like a blow to the P.gingivalis crowd. See

https://www.science.org/content/blog-po ... ng-s-great

Still enough other culprits existing, though.

Regards,
Thanks for finding and posting this; I too thought Cortexyme had an intriguing idea. Here's the excerpt on the results. Whenever the results are listed as "an improvement" and not "a statistically significant improvement", it means that they are within the range of chance variation. That probably explains the 75% drop in their stock price the author noted!
In the subgroup of patients who tested positive in their saliva for the bacterium (which is also involved in gum disease), there was improvement in the highest-dose group on one Alzheimer's rating scale (ADAS-Cog11) but no improvement on the other rating (ADCS-ADL), and that's hard to rationalize as a real effect, to be honest.
4/4 and still an optimist!
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