Welcome and a warm hug, Dee, from someone who could be your genetic cousin, at age 69 with ApoE 4/4. (Given how many kids my maternal great-grandparents and grandparents had, that's not a big stretch!) Like you, " it would actually be harder to find people who didn't develop it (on my mother's side) than people who did."dee wrote:Hi. I'm Dee. I'm not use to using forums like this, so I hope you will all bear with me while I learn how to use it. I have not yet been tested for the APOE-4 gene, but seeing that there is a link between it and severe Covid has convinced me I should. Alzheimer's runs in my family. It would actually be harder to find people who didn't develop it (on my mother's side) than people who did...
I turned 60 this year. I've gone back and forth on testing for a long time, but I am sure now that it's the right thing to do. I am absolutely terrified, but I already living with the assumption that AD is coming for me. I might as well be sure. It should catapult me into doing the work that might stave off the disease long enough for a good therapy or maybe even a cure to be developed. You know, that whole exercise/diet thing.
Anyway. Sad to be here. But glad that there's a soft place to land as we move along on this journey. It's very, very scary.
dee wrote:Thank you for the advice and the empathy, NF52. I found out last night that I am 3/4. I will probably cry a lot this week. I am so freaking scared.
Hi again dee,dee wrote:Thank you for the advice and the empathy, NF52. I found out last night that I am 3/4. I will probably cry a lot this week. I am so freaking scared.
I'm trying to process. My mother and her sister (the one who died from the disease) both fought the good fight before it came. For my mother it was mostly diet. She also tried estrogen therapy, too, back in the day when we thought that would help. My aunt was the exercise queen. She was still going to kick boxing 3 times a week in the first facility she was in.
So. I guess I will do both of those things too (diet, not estrogen), and instead of thinking "it didn't work" try to focus on, "maybe it worked and held the disease off until their 70s". My mother was a big drinker too, and that seems like a bad thing for people with the apoe-4 allele. So after I bury myself in a bottle for a week, I guess I will cut alcohol out except for a glass of wine or two on holidays. And maybe see if I can get into a drug trial.
Damn, this is hard. The worst is what I know it will do to my kids and husband. The best I can for them, I guess, is give them a fight. Plan for the worst, but fight for the best.
I am so glad I found this site.
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohortsThe Generation Study elected to disclose the following “lifetime” risks of MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4.. and 10%–15% for individuals with APOE-e3/e3, -e3/e2, and -e2/e2 (with a note that risk might be lower for those with APOE-e2/e3 and -e2/e2).
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