No response to histamine itself... not sure what that means and why I get relief from zyrtec, an antihistamine.Hmmm, assuming no histamine after allergen exposure, or even no reaction to histamine itself (?)
Julie, I have MCAS too and not Ige tested response. If you read the book it will answer a whole bunch of questions for you. I'm off all my MCAS and POTS medicines for 2 months now. I have been hospitalized in ICU for MCAS. So being off everything is amazing for me. My brain function has improved dramatically. And my pain isn't any worse off things. Histamine actually affects the Autoimmune System and Inflammation. It turns on Suppressor T Cells that help inflammation. And histamine is needed to trigger that. I worry what I may have done being on antihistamines for over 8 years non stop, out of ignorance. I did further research and histamine is being used to treat ALS, leukemia, cancer, MS and other things. It's a work in progress, but there is progress.
Indywoman wrote: 7. Most of the reports have a normative database of "thousands of healthy cohorts" that you will be compared/contrasted with in these reports, although I have not delved any more into where the healthy cohorts came from, how healthy is defined, and whether they are adding to that database.
Cox recently published a study that exploits another extension of the biobank’s original goals. In April 2016, organizers started to invite thousands of the participants back to take detailed MRI scans of their bodies, brains and other organs and add them to the database. Some 40,000 of the original volunteers have been scanned this way so far, and the project wants to make that 100,000 by 2022. Some of these volunteers also agreed to take a battery of psychological tests when they returned — to probe reasoning and intelligence with questions not asked in the original assessment. Cox and his colleagues took advantage of this to revisit one of the most controversial historic questions in psychology: Does a bigger brain make someone smarter? (Spoiler: It does, but not much.) Particularly important, the research showed, is the structure of white matter and the relative size of individual regions such as parts of the frontal cortex.
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To do this analysis, the scientists compared the test scores and brain volumes of more than 18,000 people — way more than had ever been gathered for such a study before. At a stroke, Cox says, the biobank’s massive numbers address one of the strongest criticisms of findings based on MRI scans — that they include too few people to give reliable results.
“It’s the biggest dataset there is,” says Lisa Nobis, a neuroscientist at the University of Oxford. And it shows the way that science is going. “When MRI first came out, you could get a paper in Nature or Science with just 15 people. But in the last few years, studies have shown that less than 50 people is not reliable at all” as a general rule. She is using the biobank scans to build up a picture of how the brain’s hippocampus shrinks with age and with dementia. The plan is to produce a reference tool of normal hippocampus size for different age groups that future clinicians can use to spot problems earlier.
It’s the kind of study, Nobis says, that can only be done with a very large sample size. Scientists’ attempts to boost numbers of brains by combining results from sets of smaller MRI studies run into their own set of problems: Technical differences between the way scans are done in different centers often make it difficult to meaningfully compare them. [Emphasis added]
In fact, if in the fairly distant future you run a new MRI to compare it with your NeuroQuant baseline, then if CorTechs is using much, much larger reference populations coming out of big data studies, then the comparison won't be apples to apples. So will NeuroQuant just continue to use what will be an outdated dataset so people can make comparisons over time, despite what will become outdated percentiles? Does their dataset already change from version 1 to version 2 to version 3, or are the changes only more display oriented using the same data?
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