Gut Bacteria, Amyloid and Alzheimer's

[J11]

I can see many on forum are already aware of this connection, though this article helps to make the connection in a yet more definitive style.

https://www.eurekalert.org/pub_releases ... 111320.php

https://content.iospress.com/articles/j ... /jad200306

"Results:Amyloid SUVR uptake was positively associated with blood LPS (rho≥0.32, p≤0.006), acetate and valerate (rho≥0.45, p < 0.001), pro-inflammatory cytokines (rho≥0.25, p≤0.012), and biomarkers of endothelial dysfunction (rho≥0.25, p≤0.042). In contrast, it was negatively correlated with butyrate (rho≤–0.42, p≤0.020) and the anti-inflammatory cytokine IL10 (rho≤–0.26, p≤0.009)."

I suspect many will be way ahead of me on this one. How do you increase butyrate levels?

[Tincup]

How do you increase butyrate levels?

Dietary prebiotic fibers to be fermented in the gut. More

[J11]

Tincup, thank you very much for your post.
Eat your fiber.

Is this strategy part of the AD treatment protocol followed by those on forum?

[Tincup]

Is this strategy part of the AD treatment protocol followed by those on forum?

There are diverse ideas on this forum aw to what to eat. My wife and I are Gundry patients and this applies to his suggestions also to Bredesen's Keto-Flex suggestions. His books 1 & 2

[J11]

Tincup, thank you very much. There are so many highly knowlegable posters like you on forum that it is such a pleasure to be part of this community.

One additional request: Might you have any suggestions for helping with asthma? Over the last year or so I have been having trouble with asthma. I went to a doctor a year ago and the doctor was unable to find anything that might explain what I was experiencing. I had a cold about that time, though I think that the problem has been present in an asymptomatic form even previous to my cold.

It is very odd. During the day I have almost no symptoms when involved in regular activities. I typically would never struggle for breath during the day when engaged in normal activities. I would only notice a problem if I start to try to work my cardiorespiratory system.
I would then notice some wheezing. If I try and force an exhale, then I am obstructed about half way through an exhale. My spirometer tells me that I am at about 450 on the PEV which apparently is far below my expected level which should be in the ~550s+.

Only real problem is with nightime breathing which can feel somewhat constricted upon awakening.

I have stocked up on Vitamin C, NAC, glutathionine (all oral tablets), though none of these appear to have done much.

I notice that recently my eczema appears to have flared up again. This is my second round of it; the other one appeared about
3-5 years ago and seemed to disappear by itself even when the online doctor suggested that it was probably incurable (I think vitamin D might have helped treat it). This flare up seems much less severe than before. In my last flareup every time I got it wet it made it worse.

There might be preexisting dental issues and diet issues, though these are only guesses as I actually have no particular reason to expect either of these; it is just that I really am stuck for an explanation for what might be causing this. The doctor was stumped as well. I do not think it is COVID or some other lingering respiratory infection thought this is a possibility.

Anything that you might be able suggest would be greatly appreciated.

[Tincup]

Might you have any suggestions for helping with asthma? Over the last year or so I have been having trouble with asthma. I went to a doctor a year ago and the doctor was unable to find anything that might explain what I was experiencing. I had a cold about that time, though I think that the problem has been present in an asymptomatic form even previous to my cold.

May take a moment, but I'll put something together, as I have ideas.

[Tincup]

Might you have any suggestions for helping with asthma

More than you may want, will keep you busy for a while.

The best idea is with breathing to increase CO2 tolerance. In almost all cases, the urge to breathe is caused by increased CO2 in the blood, not lack of O2. This brain is actually sensing serum pH and as it gets more acidic, it will cause the urge to breathe. This can be trained - think of free divers as an endpoint.

Turns out that CO2 relaxes smooth muscles and also more serum CO2 (lower pH) will allow more oxygen to get into the cells. This is because of the Bohr Effect and will cause a rightward shift in the oxy-hemoglobin disassociation curve.

Many, if not most, folks with asthma overbreathe. Breathing instructor, Patrick McKeown, has done a huge amount of work in this area. I will list some of his references:

Video

Guided session mp3

Book Close Your Mouth
Childrens' book ABC to be Asthma Free
Clinical trials
Book Close Your Mouth
Book Sleep with Buteyko (Buteyko was a Russian doctor who did a lot of work on this)

This may sound crazy, but tape your mouth at night to make sure you breathe through your nose. Here is tape I've used for years.
Carol, the proprietress of the correct breathing site will do remote instruction

Patrick has a bunch of podcasts under the Oxygen Advantage website - more directed at athletes, but same idea of increased CO2 tolerance and reduced breathing. He has a great book by that title. The Oxygen Advantage FB group.
Cadence Breathing
Breathing Mechanics
More of Patrick's stuff on YouTube.

A T1 diabetic reduced his blood sugar - A1c - by changing his breathing.
More videos. He's reviewed a lot of the science on it.

Lastly, not a "how to" book, but one of the best books on breathing ever.

[SusanJ]

Might you have any suggestions for helping with asthma?

Just anecdotal, do you eat/drink dairy? When I first went dairy-free, and poked around some forums, I saw people saying it helped their asthma.