The best diet for ApoE4s -Precision Nutrition - latest paper

[NoNotMe]

Welcome Karlrad!
We are so glad you have shared your knowledge about the best diets for APOE. This is information is so valuable to our community. You've found the right platform for idea sharing as we have so many curious learners! We encourage you to stay active by posting for the benefit of all! Here are some useful links to familiarize you with the site and stay engaged.

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[Karlrad]

Hi!

By the way, Dale Bredesen MD's program is excellent.

Ficus sycomorus figs, Ziziphus spp. fruits, and Moringa spp. leaves all have adequate protein.

Since these foods are only partially available in the USA, such as dried Moringa leaf in health food stores or fresh leaves in some southernmost areas, and jujubes are only available in Asian markets; other less optimal foods would need to be included. Grocery stores almost exclusively sell fruits and vegetables that are lower in protein. Broccoli, raspberries, blackberries, spinach, etc. have a fair amount of protein.

There are many other fruits and vegetables that would be extremely good for treating Alzheimer's/dementias. Pomegranate inhibits HSV-1. Salads of purslane leaf are highly effective at inhibiting Candida albicans, and somewhat inhibits HSV-1.

Substances in fruits and vegetables also feed F. prauznitzii A2-165 which produces butyrate and immune substances. In the Bredesen program, ketosis is promoted, which increases the ketone beta hydoxybutyrate. Butyrate esters rapidly increases butyrate, but may not reach the colon. Many other factors in the program promote some increase in butyrate as well. Butyrate is extremely important for colonocytes and brain health too. In Ayurvedic Panchakarma treatment, kitchari loaded with ghee (containing high amounts of butyrate) is often exclusively eaten for several weeks to restore colon health.

[Karlrad]

Hi!

By the way, Dale Bredesen MD's program is excellent.

Ficus sycomorus figs, Ziziphus spp. fruits, and Moringa spp. leaves all have adequate protein.

Since these foods are only partially available in the USA, such as dried Moringa leaf in health food stores or fresh leaves in some southernmost areas, and jujubes are only available in Asian markets; other less optimal foods would need to be included. Grocery stores almost exclusively sell fruits and vegetables that are lower in protein. Broccoli, raspberries, blackberries, spinach, etc. have a fair amount of protein.

There are many other fruits and vegetables that would be extremely good for treating Alzheimer's/dementias. Pomegranate inhibits HSV-1. Salads of purslane leaf are highly effective at inhibiting Candida albicans, and somewhat inhibits HSV-1.

Substances in fruits and vegetables also feed F. prauznitzii A2-165 which produces butyrate and immune substances. In the Bredesen program, ketosis is promoted, which increases the ketone beta hydoxybutyrate. Bredesen also suggests consuming butyrate. Consuming butyrate esters rapidly increases butyrate, but may not reach the colon were butyrate is also needed. Studies also show that butyrate and beta hydroxybutyrate have different effects. Many other factors in the program promote some increase in butyrate as well. Butyrate is extremely important for colonocytes and brain health too. In Ayurvedic Panchakarma treatment, kitchari loaded with ghee (containing high amounts of butyrate) is often exclusively eaten for several weeks to restore colon health.

[Karlrad]

An optimal diet for APOE E4/4 will include daily foods that inhibit herpesviruses. These include pomegranate fruit, Moringa leaf, purslane leaf, heal all leaf, decaffeinated green tea, lemon balm tea, tulsi tea, etc. Matthew Horne MD recommends that people consider taking 200 mg acyclovir daily to suppress HHV-1, etc. An optimal diet will include foods shown to reduce other brain and gut pathogens, such as Ficus sycomorus figs, Ziziphus spp. jujube fruits, Ceylon cinnamon, oregano leaf, broccoli sprouts, elderberry juice, turmeric with black pepper, black pepper tea, hibiscus tea, mugwort, mugwort tea, raw garlic, etc. An optimal diet will feed Faecalibacterium prausnitzii with 1-kestose, etc. from raspberries, watermelon, cherries, garlic, etc. An optimal diet will be high in resistant starches, such as slightly green bananas, etc. An optimal diet will be low in the non-essential amino acid arginine because arginine promotes HHV-1.

Wozniak and Itzhaki showed that people with APOE E4/4 are much more susceptible to facial lesions and brain infections with HHV-1 (herpes). Wozniak showed that HHV-3 (chickenpox) and HHV-4 (mono) causes more damage in APOE E4/4. HHV-3 causes arterial damage that would promote a more permeable blood-brain-barrier, microstrokes, etc. HHV-4 causes immune dysfunction, Burkitt lymphoma, thyroid disorders, etc. HHV-1, HHV-4 and other herpesviruses cause many early deaths from miscarriages, congenital infections, cancer, immune dysfunction, etc. The nationwide Taiwan medical records study concluded that 90.8% of Alzheimer's/dementias could be prevented with prolonged treatment with acyclovir, valacyclovir, etc. in the subset of people very susceptible to facial herpes lesions (per Wozniak this is people with APOE E4/4). Acyclovir, etc. also inhibits HHV-3, etc. Active infection with herpesviruses often does not produce facial lesions, etc. Similar to infection with Plasmodium spp. parasites (malaria) promoting the "sickle-cell" gene, it appears that herpesvirus infections promoted the spread of APOE E3 and APOE E2.

Food does have a large effect. Ancient ancestors eating meat would have had more infections, increased gum infections entering the brain, etc. Treponema spp., a spiral boring bacteria, often enters the brain through the gums. P. gingivalis, etc., etc. also may enter the brain through the mouth. HHV-1 often enters the brain through the olfactory nerve. Butchering and eating animals likely introduced hundreds of pathogens into the human population. The much later addition of grains, etc. would have accelerated the spread of APOE E3 and E2 mutations due to high arginine, gum disease, gut diseases, etc. Processed grains (such as modern bread...bread was once made from drying Ziziphus spp. fruit, etc.), processed sugar, etc. are excellent at promoting gum diseases and tooth diseases, especially without flossing and dental care.

Optimal foods need to inhibit newly introduced pathogens because other infections burden the immune system. Early modern medical procedures, such as dissecting diseased animals and early vaccines, likely introduced many pathogens into the human population. For example, SV40 which causes mesothelioma with or without asbestos, was spread into the human population in the early oral polio vaccines. Modern commercial animal foods production, handling raw or even pasturized foods, has likely spread many pathogens into the human population. For example, a large percentage of the USA cattle are infected with bovine leukemia virus, while in Europe cattle with bovine leukemia virus were killed. Bovine leakemia virus appears to cause breast cancer, etc. in humans. Optimal foods may include Artemisia annua leaf, etc.

An optimal diet must minimize certain plants with plant defenses to being eaten, both from substances they produce to pathogens. Specific food processing was discovered to handle some of these defenses, such as sprouting, fermenting (although this was generally for preserving food), and cooking. However, specific raw plant foods are likely the optimal diet.

An optimal diet will provide abundant butyrate from colonic fermentation while also promoting liver-produced ketones. Some ketogenic diets may be a less than optimal diet for APOE E4/4. Meat and most oils in larger amounts inhibit Faecalibacterium prausnitzii A2-165. This bacteria produces butyrate and immune substances. Pharmaceutical antibiotics reduce or elliminate this beneficial bacteria. Many ketogenic diets do increase the liver-produced ketone beta hydroxybutyrate, but this does not supply butyrate needed by colonocytes. This may lead to leaky gut with LPS, spores, etc. entering the bloodstream. Ketogenic diets do promote some vegetables that feed F. prausnitzii A2-165. A high meat, eggs, animal protein diet has been shown to always feed Bilophila wadsworthia and pathogens that damage arteries. With HHV-3 causing increased artery damage in APOE E4/4, additional damage from TMAO, etc. should be minimized. Arterial damage from TMAO, etc. also causes 7-Dehydrocholesterol to get stuck in the arterial wall instead of circulating to the skin surface for transformation into previtamin D3. This may result in certain hormone imbalances, etc.

[nerdymel23]

Also, here's a short (less than 5 minutes) video abstract given by the author: Precision Nutrition for Alzheimer's Prevention in ApoE4 carriers - Video Abstract

Thank you for sharing this information. Very helpful!

[JamesR]

One thing that struck me about this very interesting paper was the absence of any mention of Curcumin. I had thought that Isaacson believed it was useful. Has his opinion changed? Or, am I perhaps remembering incorrectly?
The other thing that struck me was the amount of Resveratrol they were recommending (2 gms!). Is anyone using quite that much?
Thanks.

This https://content.iospress.com/articles/j ... /jad200711 suggests that in 2020 Isaacson was still in favor of Theracurmin, and provides some evidence thereof.