Hi Elevation, I'm not sure what the source of your information was, but it seems inaccurate. The website for PPD Orlando Clinical study opportunities currently shows no trials of any kind.Elevation wrote:I believe this same study is now being offered in a research facility in Orlando.
100 W Gore Street Suite 202 Orlando FL 32806
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Elevation wrote:I received a call from Sarah recently informing me of this study....I questioned her...she assured me it was the same study. I did not proceed so don’t really know more.
ApropoE4 wrote:Results from a second generation investigational gene therapy program show effective delivery of APOE2, the gene associated with protection against the development of Alzheimer's disease, while also targeting and silencing APOE4, the gene that increases risk of developing the disease. A 40% reduction was observed in APOE4 expression, while APOE2 expression was maintained, suggesting APOE2 was resistant to microRNAs (miRNAs) silencing. The efficacy of gene silencing by miRNAs targeting APOE4 was evaluated by inserting miRNA into the AAV vector expression cassette.
ApropoE4 wrote: To add to NF52's great summary - the trial hasn't shown success in 40% of participants - rather it's shown APOE4 expression was down by 40% on average among participants, while APOE2 expression was maintained at least over the months that have passed.
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