johnseed wrote:Is there any way to search for "early onset"?
johnseed wrote:Not sure if there's a more appropriate place to ask this question than starting a new topic...
A friend's mother just died with early onset dementia and her GP told her that she has one chance in 2 of the same. He must be convinced its genetic though I'm pretty sure my friend hasn't had her genome sequenced. I was wondering if there was any discussion on this site so I searched on early onset and got 570 hits with "early" and "onset". So I tried searching on "early onset" (in inverted commas) hoping to weed out those posts that contained "early" and "onset" not adjacent to each other. However, I still got 570 hits.
Is there any way to search for "early onset"?
And do any of you know where I can get reliable information about early onset dementia?
Hi John,johnseed wrote:Not sure if there's a more appropriate place to ask this question than starting a new topic...
A friend's mother just died with early onset dementia and her GP told her that she has one chance in 2 of the same....
And do any of you know where I can get reliable information about early onset dementia?...
Below is an important fact from the Alzheimer's Association about how few cases of EAOD are caused by familial, dominant genes: [Emphasis added.]Early-Onset Alzheimer's Disease
Early-onset Alzheimer’s disease is rare, representing less than 10 percent of all people with Alzheimer’s. It typically occurs between a person’s 30s and mid-60s. Some cases are caused by an inherited change in one of three genes.
The three single-gene mutations associated with early-onset Alzheimer’s disease are:
Amyloid precursor protein (APP) on chromosome 21
Presenilin 1 (PSEN1) on chromosome 14
Presenilin 2 (PSEN2) on chromosome 1
Mutations in these genes result in the production of abnormal proteins that are associated with the disease. Each of these mutations plays a role in the breakdown of APP, a protein whose precise function is not yet fully understood. This breakdown is part of a process that generates harmful forms of amyloid plaques, a hallmark of Alzheimer’s disease.
A child whose biological mother or father carries a genetic mutation for one of these three genes has a 50/50 chance of inheriting that mutation. If the mutation is in fact inherited, the child has a very strong probability of developing early-onset Alzheimer’s disease.
For other cases of early-onset Alzheimer’s, research has shown that other genetic components are involved. Studies are ongoing to identify additional genetic risk variants.
https://www.alz.org/alzheimers-dementia/what-is-alzheimers/younger-early-onsetCauses of early-onset including genetics
Doctors do not understand why most cases of early-onset Alzheimer's appear at such a young age. But in a few hundred families worldwide, scientists have pinpointed several rare genes that directly cause Alzheimer's. People who inherit these rare genes tend to develop symptoms in their 30s, 40s and 50s. When Alzheimer's disease is caused by deterministic genes, it is called “familial Alzheimer's disease,” and many family members in multiple generations are affected.
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